| Exercise, weight loss, and changes in body composition in mice: phenotypic relationships and genetic architecture. | |
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MedLine Citation:
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PMID: 21156834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The regulation of body weight and composition is complex, simultaneously affected by genetic architecture, the environment, and their interactions. We sought to analyze the complex phenotypic relationships between voluntary exercise, food consumption, and changes in body weight and composition and simultaneously localize quantitative trait loci (QTL) controlling these traits. A large (n = 815) murine advanced intercross line (G(4)) was created from a reciprocal cross between a high-running line and the inbred strain C57BL/6J. Body weight and composition (% fat, % lean) were measured at 4, 6, and 8 wk of age. After measurements at 8 wk of age, mice were given access to running wheels, during which food consumption was quantified and after which body weight and composition were assessed to evaluate exercise-induced changes. Phenotypic correlations indicated that the relationship between exercise and overall change in weight and adiposity depended on body composition before the initiation of exercise. Interval mapping revealed QTL for body weight, % fat, and % lean at 4, 6, and 8 wk of age. Furthermore, QTL were observed for food consumption and changes in weight, % fat, and % lean in response to short-term exercise. Here we provide some clarity for the relationship between weight loss, reduction in adiposity, food consumption, and exercise. Simultaneously, we reinforce the genetic basis for body weight and composition with some independent loci controlling growth at different ages. Finally, we present unique QTL providing insight regarding variation in weight loss and reduction in adiposity in response to exercise. |
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Authors:
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Scott A Kelly; Derrick L Nehrenberg; Kunjie Hua; Theodore Garland; Daniel Pomp |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-12-14 |
Journal Detail:
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Title: Physiological genomics Volume: 43 ISSN: 1531-2267 ISO Abbreviation: Physiol. Genomics Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-25 Completed Date: 2011-08-24 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 9815683 Medline TA: Physiol Genomics Country: United States |
Other Details:
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Languages: eng Pagination: 199-212 Citation Subset: IM |
Affiliation:
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Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA. scottkelly@unc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity
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genetics Animals Body Composition / genetics*, physiology* Body Weight / genetics Feeding Behavior Mice Mice, Inbred C57BL Phenotype* Physical Conditioning, Animal / physiology* Quantitative Trait Loci / genetics Regression Analysis Weight Loss / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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5T32-MH-075854-04/MH/NIMH NIH HHS; DK-056350/DK/NIDDK NIH HHS; DK-076050/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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