Document Detail


Exercise under hot conditions: a major threat to the immune response?
MedLine Citation:
PMID:  12094129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It seems likely that the disturbances of immune response induced by prolonged competitive exercise are exacerbated if athletes also face the stress of hot environmental conditions. We have investigated this question by manipulating the exercise-induced increases of body temperature in a climatic chamber and by submersion of exercisers in a large water-bath. Hot conditions increase the stress of a given bout of exercise, as assessed by personal perceptions, objective (heart rate variability) measures of autonomic nerve balance, and the secretion of "stress" hormones, with a parallel increase in effects upon critical lymphocyte subsets. Changes in the immune response show substantial correlations with plasma concentrations not only of epinephrine (which modulates the adhesiveness of peripherally sequestered lymphocytes), but also with norepinephrine. The latter hormone may mobilize leukocytes from the spleen and lymph glands, or it may act by increasing cardiac output and thus intravascular shear forces. Given the cumulative impact of various environmental stressors upon the immune system, every effort should be made to minimize the athlete's exposure to stresses other than the exercise to be performed. In some circumstances, the use of medications to reduce the overall stress response may also be warranted.
Authors:
R J Shephard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of sports medicine and physical fitness     Volume:  42     ISSN:  0022-4707     ISO Abbreviation:  J Sports Med Phys Fitness     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-07-02     Completed Date:  2002-12-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376337     Medline TA:  J Sports Med Phys Fitness     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  368-78     Citation Subset:  IM    
Affiliation:
Faculty of Physical Education and Health and Department of Public Health Sciences, University of Toronto, Toronto, Canada. royjshep@shaw.ca
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MeSH Terms
Descriptor/Qualifier:
Body Temperature Regulation / physiology
Cell Adhesion Molecules / metabolism
Cell Movement / physiology
Cytokines / metabolism
Exercise / physiology*
Heat Stress Disorders / physiopathology*
Hormones / blood
Humans
Killer Cells, Natural / immunology
Leukocyte Count
Lymphocyte Subsets / immunology
Naltrexone / therapeutic use
Stress, Physiological / immunology
beta-Endorphin / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Cytokines; 0/Hormones; 16590-41-3/Naltrexone; 60617-12-1/beta-Endorphin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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