Document Detail


Exercise training and tumour metastasis in mice: influence of time of exercise onset.
MedLine Citation:
PMID:  8297117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was designed to investigate the factor of timing of activity onset in determining the effects of exercise on experimental metastases. After 9 weeks of wheel running activity (W) or remaining sedentary (S), male C3H/He mice received an i.v. injection of CIRAS 1 tumor cells. Mice were then randomized into sedentary and wheel running groups (SS, SW, WS, WW) for a further 3 weeks. Although the average number of lung tumours did not differ by activity condition, the groups exercised prior to tumour injection had a greater incidence in the lowest tertile of tumour distribution relative to sedentary controls (SS = 8/20 vs. WS = 16/19, p < 0.005; SS vs. WW = 14/18, p < 0.05). In a replication trial, a similar outcome was present in the lowest tertile: increased incidence of animals exercised prior to injection (SS = 3/9 vs. WW = 7/9: p < 0.05). These data suggest that exercise training before, but not after, i.v. exposure to tumour reduces the number of lung metastases and that the timing of exercise onset influences the extent of experimental metastasis in this model.
Authors:
B MacNeil; L Hoffman-Goetz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  13     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1993 Nov-Dec
Date Detail:
Created Date:  1994-02-28     Completed Date:  1994-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  2085-8     Citation Subset:  IM    
Affiliation:
Department of Kinesiology, Faculty of Applied Health Sciences, University of Waterloo, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cytoplasmic Granules / enzymology
Esterases / metabolism
Exocytosis
Killer Cells, Natural / immunology
Lung Neoplasms / immunology,  pathology,  prevention & control*,  secondary*
Lymphocytes / enzymology
Male
Mice
Mice, Inbred C3H
Neoplasm Metastasis / immunology,  pathology,  prevention & control*
Neoplasms, Experimental / immunology,  pathology*
Physical Conditioning, Animal*
Random Allocation
Time Factors
Chemical
Reg. No./Substance:
EC 3.1.-/Esterases; EC 3.1.-/serine esterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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