Document Detail

Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery disease.
MedLine Citation:
PMID:  21450569     Owner:  NLM     Status:  Publisher    
Objective: Exercise training partially corrects endothelial dysfunction in patients with coronary artery disease (CAD). Growth factors like vascular endothelial growth factor (VEGF) as well as erythropoietin (EPO) are known to modulate the bioavailability of nitric oxide and, thereby, contribute to the maintenance of a normal vascular tone. The aim of the present study was to determine the impact of 4 weeks of exercise training on circulating growth factors and to elucidate their involvement in the training-induced changes in vasomotion in patients with CAD. Methods and results: A total of 39 patients were enrolled (training group: n = 20; control group: n = 19). At start of study and after 4 weeks, average peak flow velocity (APV) of the left internal mammary artery (LIMA) in response to acetylcholine was measured invasively in the treatment and control groups. Serum concentrations of VEGF and EPO were determined by enzyme-linked immunosorbent assay. After exercise training, LIMA APV in response to acetylcholine was increased by 93% (from 69 ± 17% at start of study to 133 ± 16% at 4 weeks, p < 0.01 vs. start of study and control). At start of study, there was no association between any of the vascular growth factors and endothelial function. However, after exercise training a close correlation was apparent between the acetylcholine-induced change in APV and EPO (r = 0.69, p < 0.01) and VEGF (r = 0.76, p < 0.01) serum concentrations. In the control group, these correlations were not evident and there was no change in endothelial function either. Conclusion: Exercise training improves agonist-mediated endothelium-dependent vasodilatation in CAD, partially through a restoration of the endothelial response to EPO and VEGF.
Ephraim B Beck; Sandra Erbs; Sven Möbius-Winkle; Volker Adams; Felix J Woitek; Thomas Walther; R Hambrecht; Friedrich-Wilhelm Mohr; Michael Stumvoll; Matthias Blüher; Gerhard Schuler; Axel Linke
Related Documents :
20926529 - Moderate doses of hgh (0.64 mg/d) improve lipids but not cardiovascular function in gh-...
20149929 - Growth hormone, prolactin and cortisol response to exercise in patients with depression.
1641069 - Plasma growth hormone and prolactin responses to graded levels of acute exercise and to...
2354779 - Caste and metamorphosis: hemolymph titers of juvenile hormone and ecdysteroids in last ...
9660159 - The effects of short-term resistance training on endocrine function in men and women.
17697029 - Post-exercise abdominal, subcutaneous adipose tissue lipolysis in fasting subjects is i...
1784879 - Exercise and heart transplantation. a review.
448449 - Selenium, vitamin e and the response to swimming stress in the rat.
2611739 - Increasing the understanding of industrial accidents: an analysis of potential major in...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-22
Journal Detail:
Title:  European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology     Volume:  -     ISSN:  1741-8275     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101192000     Medline TA:  Eur J Cardiovasc Prev Rehabil     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Heart Center, Department of Cardiology, University of Leipzig, Leipzig, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Four out of ten patients are not taking statins regularly during the 12 months after an acute corona...
Next Document:  Blood pressure variations and low blood pressure values at home after hospital discharge in older hy...