Document Detail


Exercise training reduces circulating adiponectin levels in patients with chronic heart failure.
MedLine Citation:
PMID:  19656085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High adiponectin concentrations have emerged as an independent risk factor of outcome inpatients with CHF (chronic heart failure); however, modification of adiponectin in CHF patients has not been assessed to date. The aim of the present study was to investigate the effect of exercise training on adiponectin levels in CHF patients. A total of 80 patients with CHF due to systolic dysfunction were included. The effect of 4 months exercise training was studied in 46 patients,whereas the remaining 34 untrained CHF patients served as a sedentary control group. Circulating adiponectin concentrations, exercise capacity, anthropometric data and NT-proBNP (N-terminal pro-brain natriuretic peptide) levels were assessed. Adiponectin levels were significantly higher in CHF patients compared with healthy subjects [9.3 (7.1-16.1) and 4.9 (3.9-8.6) mg/l respectively;P=0.015]. Stratification of CHF patients according to tertiles of NT-proBNP revealed an increase in adiponectin with disease severity (P<0.0001). Exercise training reduced circulating adiponectin levels in CHF patients [10.7 (7.2-17.6) mg/l before training to 9.4 (5.9-14.8) mg/l after training;P=0.013], whereas no changes were observed in the sedentary CHF group [9.0 (7.0-13.5) mg/l before training and 10.1 (6.0-15.7) mg/l after a similar time interval]. A significant time x group interaction (P=0.008) was observed for the mean change in adiponectin between the trained and untrained CHF patients. Adiponectin concentrations were positively associated with NT-proBNP and HDL (high-density lipoprotein)-cholesterol and negatively correlated with BMI (body mass index), triacylglycerols and exercise capacity. In conclusion, circulating adiponectin concentrations are higher in CHF patients compared with healthy subjects and increase with disease severity.Exercise training for 4 months lowers circulating adiponectin levels.
Authors:
An M Van Berendoncks; Paul Beckers; Vicky Y Hoymans; Nadine Possemiers; Floris L Wuytss; Christiaan J Vrints; Viviane M Conraads
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  118     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-03-22     Revised Date:  2013-06-13    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  281-9     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Antwerp University Hospital, 2650 Edegem, Belgium. An.Vanberendoncks@ua.ac.be
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood*
Case-Control Studies
Chronic Disease
Exercise*
Exercise Tolerance
Female
Heart Failure, Systolic / blood*,  rehabilitation
Humans
Lipoproteins, HDL / blood
Male
Middle Aged
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Prospective Studies
Regression Analysis
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Lipoproteins, HDL; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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