Document Detail

Exercise training protects against an acute inflammatory insult in mouse epididymal adipose tissue.
MedLine Citation:
PMID:  24674860     Owner:  NLM     Status:  Publisher    
Exercise training reduces systemic and adipose tissue inflammation. However, these beneficial effects seem to be largely tied to reductions in adipose tissue mass. The purpose of the present study was to determine if exercise training confers a protective effect against an acute inflammatory challenge. We hypothesized that the induction of inflammatory markers, such as Interleukin 6 (IL-6), SOCS3 (Suppressor of Cytokine Signaling 3) and Tumour Necrosis Factor alpha (TNFα), by the beta-3 adrenergic agonist CL 316,243 would be reduced in adipose tissue from trained mice and this would be associated with reductions in TRPV4 (Transient receptor potential cation channel 4) a protein recently shown to regulate the expression of pro-inflammatory cytokines. Exercise training (4 weeks of treadmill running, 1 hr/day, 5 days/wk) increased markers of skeletal muscle mitochondrial content and the induction of PPAR gamma co-activator 1 alpha in epididymal adipose tissue. The mRNA expression of IL-6, SOCS3 and TNFα were not different in subcutaneous and epididymal adipose tissue from sedentary and trained mice, however the CL 316, 243 mediated induction of these genes was attenuated ~50% in epididymal adipose tissue from trained mice as were increases in plasma IL-6. The effects of training were not explained by reductions in lipolytic responsiveness, but were associated with decreases in TRPV4 protein content. These results highlight a previously unappreciated anti-inflammatory effect of exercise training on adipose tissue immuno-metabolism and underscores the value of assessing adipose tissue inflammation in the presence of an inflammatory insult.
Laura Castellani; Jared Root-McCaig; Scott Frendo-Cumbo; Marie-Soleil Beaudoin; David C Wright
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-27
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  -     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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