| Exercise training prevents hyperinsulinemia, muscular glycogen loss and muscle atrophy induced by dexamethasone treatment. | |
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MedLine Citation:
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PMID: 19967395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigated whether exercise training could prevent the negative side effects of dexamethasone. Rats underwent a training period and were either submitted to a running protocol (60% physical capacity, 5 days/week for 8 weeks) or kept sedentary. After this training period, the animals underwent dexamethasone treatment (1 mg/kg per day, i.p., 10 days). Glycemia, insulinemia, muscular weight and muscular glycogen were measured from blood and skeletal muscle. Vascular endothelial growth factor (VEGF) protein was analyzed in skeletal muscles. Dexamethasone treatment evoked body weight loss (-24%), followed by muscular atrophy in the tibialis anterior (-25%) and the extensor digitorum longus (EDL, -15%). Dexamethasone also increased serum insulin levels by 5.7-fold and glucose levels by 2.5-fold compared to control. The exercise protocol prevented atrophy of the EDL and insulin resistance. Also, dexamethasone-treated rats showed decreased muscular glycogen (-41%), which was further attenuated by the exercise protocol. The VEGF protein expression decreased in the skeletal muscles of dexamethasone-treated rats and was unaltered by the exercise protocol. These data suggest that exercise attenuates hyperglycemia and may also prevent insulin resistance, muscular glycogen loss and muscular atrophy, thus suggesting that exercise may have some benefits during glucocorticoid treatment. |
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Authors:
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Matheus Barel; Ot?vio Andr? Brogin Perez; Vanessa Aparecida Giozzet; Alex Rafacho; Jos? Roberto Bosqueiro; Sandra Lia do Amaral |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-06 |
Journal Detail:
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Title: European journal of applied physiology Volume: 108 ISSN: 1439-6327 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-26 Completed Date: 2010-06-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 999-1007 Citation Subset: IM |
Affiliation:
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Department of Physical Education, School of Science, S?o Paulo State University, UNESP, Bauru, SP, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / analysis Body Weight / drug effects Dexamethasone / adverse effects*, pharmacology Exercise Test Glucocorticoids / adverse effects, pharmacology Glycogen / deficiency, metabolism* Hyperinsulinism / chemically induced*, complications, metabolism, prevention & control* Insulin / blood Insulin Resistance / physiology Male Muscle, Skeletal / chemistry, drug effects*, metabolism, pathology Muscular Atrophy / chemically induced*, complications, metabolism, prevention & control* Physical Conditioning, Animal / physiology* Rats Rats, Wistar Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Glucocorticoids; 11061-68-0/Insulin; 50-02-2/Dexamethasone; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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