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Exercise training prevents ecto-nucleotidases alterations in platelets of hypertensive rats.
MedLine Citation:
PMID:  22915168     Owner:  NLM     Status:  Publisher    
In this study, we investigated the effect of 6 weeks of swimming training on the ecto-nucleotidase activities and platelet aggregation from rats that developed hypertension in response to oral administration of L: -NAME. The rats were divided into four groups: control (n = 10), exercise (n = 10), L: -NAME (n = 10), and exercise L: -NAME (n = 10). The animals were trained five times per week in an adapted swimming system for 60 min with a gradual increase of the workload up to 5 % of animal's body weight. The results showed an increase in ATP, ADP, AMP, and adenosine hydrolysis, indicating an augment in NTPDase (from 35.3 ± 8.1 to 53.0 ± 15.1 nmol Pi/min/mg protein for ATP; and from 21.7 ± 7.0 to 46.4 ± 15.6 nmol Pi/min/mg protein for ADP as substrate), ecto-5'-nucleotidase (from 8.0 ± 5.7 to 28.1 ± 6.9 nmol Pi/min/mg protein), and ADA (from 0.8 ± 0.5 to 3.9 ± 0.8 U/L) activities in platelets from L: -NAME-treated rats when compared to other groups (p < 0.05). A significant augment on platelet aggregation in L: -NAME group was also observed. Exercise training was efficient in preventing these alterations in the exercise L: -NAME group, besides showing a significant hypotensive effect. In conclusion, our results clearly indicated a protector action of moderate intensity exercise on nucleotides and nucleoside hydrolysis and on platelet aggregation, which highlights the exercise training effect to avoid hypertension complications related to ecto-nucleotidase activities.
Andréia Machado Cardoso; Margarete Dulce Bagatini; Caroline Curry Martins; Fátima Hussein Abdalla; Daniela Zanini; Roberta Schmatz; Jessié Gutierres; Victor Camera Pimentel; Gustavo Thomé; Claudio Alberto Martins Leal; Juliano Marchi Vieira; Naiara Stefanello; Fernando da Silva Fiorin; Jucimara Baldissareli; Luiz Fernando Freire Royes; Adriane Bello Klein; Vera Maria Morsch; Maria Rosa Chitolina Schetinger
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-23
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  -     ISSN:  1573-4919     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Post-Graduation Program in Toxicological Biochemistry, Department of Chemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil.
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