| Exercise training prevents ecto-nucleotidases alterations in platelets of hypertensive rats. | |
| | |
MedLine Citation:
|
PMID: 22915168 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In this study, we investigated the effect of 6 weeks of swimming training on the ecto-nucleotidase activities and platelet aggregation from rats that developed hypertension in response to oral administration of L: -NAME. The rats were divided into four groups: control (n = 10), exercise (n = 10), L: -NAME (n = 10), and exercise L: -NAME (n = 10). The animals were trained five times per week in an adapted swimming system for 60 min with a gradual increase of the workload up to 5 % of animal's body weight. The results showed an increase in ATP, ADP, AMP, and adenosine hydrolysis, indicating an augment in NTPDase (from 35.3 ± 8.1 to 53.0 ± 15.1 nmol Pi/min/mg protein for ATP; and from 21.7 ± 7.0 to 46.4 ± 15.6 nmol Pi/min/mg protein for ADP as substrate), ecto-5'-nucleotidase (from 8.0 ± 5.7 to 28.1 ± 6.9 nmol Pi/min/mg protein), and ADA (from 0.8 ± 0.5 to 3.9 ± 0.8 U/L) activities in platelets from L: -NAME-treated rats when compared to other groups (p < 0.05). A significant augment on platelet aggregation in L: -NAME group was also observed. Exercise training was efficient in preventing these alterations in the exercise L: -NAME group, besides showing a significant hypotensive effect. In conclusion, our results clearly indicated a protector action of moderate intensity exercise on nucleotides and nucleoside hydrolysis and on platelet aggregation, which highlights the exercise training effect to avoid hypertension complications related to ecto-nucleotidase activities. |
| | |
Authors:
|
Andréia Machado Cardoso; Margarete Dulce Bagatini; Caroline Curry Martins; Fátima Hussein Abdalla; Daniela Zanini; Roberta Schmatz; Jessié Gutierres; Victor Camera Pimentel; Gustavo Thomé; Claudio Alberto Martins Leal; Juliano Marchi Vieira; Naiara Stefanello; Fernando da Silva Fiorin; Jucimara Baldissareli; Luiz Fernando Freire Royes; Adriane Bello Klein; Vera Maria Morsch; Maria Rosa Chitolina Schetinger |
Related Documents
:
|
11120898 - Glutathione in induced sputum of healthy individuals and patients with asthma. 16442588 - Effects of acute exercise on lung antioxidant enzymes in young and old rats. 10846018 - Effects of emphysema and training on glutathione oxidation in the hamster diaphragm. 22872658 - Post-exercise hypotension and sustained post-exercise vasodilation: what happens after ... 16982388 - Impact of the "planning to be active" leisure time physical exercise program on rural h... 10850838 - Effects of warm-up intensity on kinetics of oxygen consumption and carbon dioxide produ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-23 |
Journal Detail:
|
Title: Molecular and cellular biochemistry Volume: - ISSN: 1573-4919 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Post-Graduation Program in Toxicological Biochemistry, Department of Chemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prevention and treatment of mice paw edema by near-infrared low-level laser therapy on lymph nodes.
Next Document: Age-dependent down-regulation of DNA polymerase ?1 in human lymphocytes.