Document Detail

Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats.
MedLine Citation:
PMID:  22892928     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations.
METHODS: Wistar rats receiving fructose overload (F) in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) for 10 weeks or kept sedentary. These rats were compared with a control group (C). Obesity was evaluated by the Lee index, and glycemia and insulin tolerance tests constituted the metabolic evaluation. Blood pressure was measured directly (Windaq, 2 kHz), and echocardiography was performed to determine left ventricular morphology and function. Statistical significance was determined by one-way ANOVA, with significance set at p<0.05.
RESULTS: Fructose overload induced a metabolic syndrome state, as confirmed by insulin resistance (F: 3.6 ± 0.2 vs. C: 4.5 ± 0.2 mg/dl/min), hypertension (mean blood pressure, F: 118 ± 3 vs. C: 104 ± 4 mmHg) and obesity (F: 0.31 ± 0.001 vs. C: 0.29 ± 0.001 g/mm). Interestingly, fructose overload rats also exhibited diastolic dysfunction. Exercise training performed during the period of high fructose intake eliminated all of these derangements. The improvements in metabolic parameters were correlated with the maintenance of diastolic function.
CONCLUSION: The role of exercise training in the prevention of metabolic and hemodynamic parameter alterations is of great importance in decreasing the cardiac morbidity and mortality related to metabolic syndrome.
Cristiano Mostarda; Ivana Cinthya Moraes-Silva; Vera Maria Cury Salemi; Jacqueline Freire Machi; Bruno Rodrigues; Kátia De Angelis; Vera de Moura Azevedo Farah; Maria Claudia Irigoyen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  67     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-15     Completed Date:  2013-06-12     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  815-20     Citation Subset:  IM    
Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, Hypertension Unit, Heart Institute (InCor), Sao Paulo/SP, Brazil.
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MeSH Terms
Diastole / physiology
Disease Models, Animal
Fructose / adverse effects
Metabolic Syndrome X / complications*,  physiopathology
Physical Conditioning, Animal / physiology*
Rats, Wistar
Sweetening Agents / adverse effects
Ventricular Dysfunction, Left / etiology,  physiopathology,  prevention & control*
Reg. No./Substance:
0/Sweetening Agents; 30237-26-4/Fructose

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