Document Detail

Exercise training preserves coronary flow and reduces infarct size after ischemia-reperfusion in rat heart.
MedLine Citation:
PMID:  12937028     Owner:  NLM     Status:  MEDLINE    
The effect of endurance training on the resistance of the heart to left ventricular (LV) functional deficit and infarction after a transient regional ischemia and subsequent reperfusion was examined. Female Sprague-Dawley rats were randomly assigned to an endurance exercise training (Tr) group or a sedentary (Sed) control group. After 20 wk of training, hearts were excised, perfused, and instrumented for assessment of LV mechanical function, and the left anterior descending coronary artery was occluded to induce a transient regional ischemia (1 h) that was followed by 2 h of reperfusion. Throughout much of the regional ischemia-reperfusion protocol, coronary flow rates, diastolic function, and LV developed pressure were better preserved in hearts from Tr animals. During the regional ischemia, coronary flow to myocardium outside the ischemic zone at risk (ZAR) was maintained in Tr hearts, whereas it progressively fell in Sed hearts. On release of the coronary artery ligature, flow to the ZAR was greater in Tr than in Sed hearts. Infarct size, expressed as a percentage of the ischemic ZAR, was significantly smaller in hearts from Tr rats (24 +/- 3 vs. 32 +/- 2% of ZAR, P < 0.05). Mn- and CuZn-SOD protein expression were higher in the LV myocardium of Tr animals (P < 0.05 for both isoforms). Our data indicate that long-term exercise training leads to infarct sparing and better maintenance of coronary flow and mechanical function after ischemia-reperfusion.
David A Brown; Korinne N Jew; Genevieve C Sparagna; Timothy I Musch; Russell L Moore
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2003-08-22
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  95     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-05     Completed Date:  2004-07-06     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2510-8     Citation Subset:  IM    
Department of Integrative Physiology, University of Colorado, Boulder, CO 80309-0354, USA.
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MeSH Terms
Blood Pressure / physiology
Blotting, Western
Body Weight / physiology
Citrate (si)-Synthase / metabolism
Coronary Circulation / physiology*
Image Processing, Computer-Assisted
Myocardial Infarction / pathology*
Myocardial Reperfusion Injury / pathology*
Physical Conditioning, Animal / physiology*
Rats, Sprague-Dawley
Superoxide Dismutase / metabolism
Tibia / anatomy & histology
Ventricular Function, Left / physiology
Grant Support
Reg. No./Substance:
EC Dismutase; EC (si)-Synthase

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