Document Detail


Exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in hippocampus of stroke-prone hypertensive rats.
MedLine Citation:
PMID:  23367482     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One of the important organ damage of hypertension is cognitive decline. Cognitive function is determined by the function of hippocampus, and previous studies have suggested that the decrease in brain-derived neurotrophic factor (BDNF) in the hippocampus causes cognitive decline. Protection against cognitive decline is reported not only in pharmacological therapy but also in exercise training or calorie restriction. The aim of the present study was to determine whether exercise training plus calorie restriction cause synergistic protection against cognitive decline via BDNF in the hippocampus or not. Exercise training for 28 days improved cognitive decline determined by Morris water maze test via up-regulation of BDNF in the hippocampus of stroke-prone spontaneously hypertensive rats, whereas calorie restriction for 28 days did not. However, exercise training plus calorie restriction causes the protection against cognitive decline to a greater extent than exercise training alone. In conclusion, exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in the hippocampus of stroke-prone hypertensive rats.
Authors:
T Kishi; K Sunagawa
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2012     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-09-17     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6764-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain-Derived Neurotrophic Factor / metabolism*
Caloric Restriction*
Cognition
Cognition Disorders / prevention & control*
Disease Models, Animal
Food Deprivation*
Hippocampus / metabolism*,  pathology
Hypertension / physiopathology
Male
Maze Learning
Models, Statistical
Physical Conditioning, Animal*
Rats
Rats, Inbred SHR
Stroke / metabolism*
Up-Regulation
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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