| Exercise training normalizes vascular dysfunction and improves central adiposity in obese adolescents. | |
| | |
MedLine Citation:
|
PMID: 15145107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: We sought to characterize the impact of obesity on vascular function in adolescents and to determine whether an exercise program reverses abnormalities in endothelial function. BACKGROUND: Obesity, a major modifiable risk factor for cardiovascular disease, is epidemic in Western societies, with rapid rates of increase in the young. Atherosclerosis begins in childhood, and endothelial dysfunction is its earliest detectable manifestation. METHODS: The influence of eight weeks of circuit training (CT) was examined in 19 obese subjects (14.3 +/- 1.5 years), using a randomized, crossover protocol. Functional capacity and muscular strength were assessed by standard techniques. Body composition was examined using anthropometric measures and dual-energy X-ray absorptiometry. Conduit vessel endothelial function was assessed using high-resolution ultrasound and flow-mediated dilation (FMD) of the brachial artery. RESULTS: Circuit training decreased abdominal and trunk fat and significantly improved fitness and muscular strength (p < 0.05). In the obese group, FMD was significantly impaired relative to control subjects (n = 20) at entry (5.3 +/- 0.9% vs. 8.9 +/- 1.5%, p < 0.05) and was normalized after CT (8.8 +/- 0.8%, p < 0.05). CONCLUSIONS: Circuit training improved functional capacity, muscular strength, and body composition in obese adolescents. Furthermore, conduit vessel function was normalized after exercise training. If vascular dysfunction is an integral component of the pathogenesis of vascular disease, this study supports the value of an exercise program in the management of obese adolescents. |
| | |
Authors:
|
Katie Watts; Petra Beye; Aris Siafarikas; Elizabeth A Davis; Timothy W Jones; Gerard O'Driscoll; Daniel J Green |
Related Documents
:
|
20153487 - Effect of 2 weeks of sprint interval training on health-related outcomes in sedentary o... 18585007 - Combined effects of hla-cw6, body mass index and waist-hip ratio on psoriasis vulgaris ... 19436537 - A needs assessment for obesity-related anticipatory guidance in the paediatric emergenc... 11461277 - Importance of interactions for free-volume and end-group effects in polymers: an equili... 22835267 - Supplementation of acqua lete® (bicarbonate calcic mineral water) improves hydration s... 1401617 - Physiologic changes with maximal exercise in asymptomatic valvular aortic stenosis asse... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: 43 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2004 May |
Date Detail:
|
Created Date: 2004-05-17 Completed Date: 2004-06-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1823-7 Citation Subset: AIM; IM |
Affiliation:
|
Human Movement and Exercise Science, University of Western Australia, Crawley, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue
/
physiopathology Adolescent Cross-Over Studies Endothelium, Vascular / physiopathology Exercise Therapy / methods* Female Humans Male Obesity / complications, physiopathology, therapy* Vascular Diseases / etiology, physiopathology, therapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prognostic value of the metabolic syndrome in essential hypertension.
Next Document: High lipoprotein(a) levels and small apolipoprotein(a) sizes are associated with endothelial dysfunc...