| Exercise training modulates the nitric oxide synthase profile in skeletal muscle from old rats. | |
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MedLine Citation:
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PMID: 19304939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of exercise training on the nitric oxide synthase (NOS) isoform profile in aging fast-twitch (white gastrocnemius [WG]) and slow-twitch (soleus [SOL]) muscle have not been investigated. Six-month and 27-month male Fischer-344 rats were divided into the following groups: young sedentary (YS), young treadmill exercise trained for 12 weeks, old sedentary (OS), and old exercise trained (OE). Inducible NOS (iNOS) protein expression and activity were significantly higher in OS compared with YS, whereas exercise training significantly reduced iNOS protein and activity levels in the WG. Neuronal NOS protein expression decreased with aging in WG but was upregulated significantly with exercise training in OE for both WG and SOL. Endothelial NOS (eNOS) protein levels were depressed in WG of old rats but were higher in OE than in OS. eNOS was unaffected by aging or exercise in the SOL. Our results indicate that endurance exercise training attenuates age-induced alterations of NOS isoforms with a greater response in fast-twitch compared with slow-twitch muscle. |
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Authors:
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Wook Song; Hyo-Bum Kwak; Jong-Hee Kim; John M Lawler |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-03-20 |
Journal Detail:
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Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 64 ISSN: 1758-535X ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-09 Completed Date: 2009-05-18 Revised Date: 2013-06-02 |
Medline Journal Info:
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Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 540-9 Citation Subset: AIM; IM |
Affiliation:
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Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, and Intercollegiate Faculty of Nutrition, Texas A&M University, College Station, TX 77843-4243, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gene Expression Gene Expression Regulation, Enzymologic* Isoenzymes Male Muscle, Skeletal / enzymology* Nitric Oxide Synthase / genetics* Physical Conditioning, Animal* Rats |
| Grant Support | |
ID/Acronym/Agency:
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AR054084/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; EC 1.14.13.39/Nitric Oxide Synthase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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