| Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure. | |
| | |
MedLine Citation:
|
PMID: 21450574 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: In chronic heart failure (CHF), cardiac cachexia is often associated with the terminal stage of this disease. In animal studies it has been demonstrated that myostatin, a key regulator of skeletal muscle mass, is elevated in advanced stages of this syndrome. Design: The aim of the present study was to investigate the expression of myostatin in patients with late stage CHF (NYHA IIIb) in comparison to healthy subjects. Furthermore the effects of physical exercise on myostatin were analyzed. Methods: Twenty-four patients were either randomized to a sedentary control group (CHF-S) or exercise training (CHF-E). At baseline and after 12 weeks mRNA and myostatin protein in the peripheral skeletal muscle as well as myostatin serum concentration were measured. Furthermore 12 age-matched healthy men were compared to all patients at baseline (HC). Results: CHF patients showed a two-fold increase of myostatin mRNA (p = 0.05) and a 1.7-fold (p = 0.01) augmentation of protein content in skeletal muscle compared to healthy subjects. In late-stage CHF, exercise training led to a 36% reduction of the mRNA and a 23% decrease of the myostatin protein compared to baseline. The serum concentration of myostatin revealed no significant alteration between the groups. Conclusion: In the skeletal muscle, myostatin increases significantly in the course of CHF. The observed effects of a significant reduction of myostatin in skeletal muscle after 12 weeks of exercise training demonstrate the reversibility of molecular changes that might be able to halt the devastating process of muscle wasting in chronic heart failure. |
| | |
Authors:
|
Karsten Lenk; Sandra Erbs; Robert Höllriege; Ephraim Beck; Axel Linke; Stephan Gielen; Sven Möbius Winkler; Marcus Sandri; Rainer Hambrecht; Gerhard Schuler; Volker Adams |
Related Documents
:
|
12534544 - Increased airway inflammatory cells in endurance athletes: what do they mean? 16765074 - Inhaled corticosteroids reduce asthma-associated airway hyperperfusion through genomic ... 15721394 - The use of sterically stabilized liposomes to treat asthma. 10989864 - Successful pharyngeal pulse oximetry in low perfusion states. 10441084 - The relationship between mechanical work and energy expenditure of locomotion in horses. 11273914 - Voluven, a lower substituted novel hydroxyethyl starch (hes 130/0.4), causes fewer effe... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-14 |
Journal Detail:
|
Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: - ISSN: 1741-8275 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
University of Leipzig, Heart Center, Department of Internal Medicine/Cardiology, Leipzig, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of carvedilol on oxygen uptake and heart rate kinetics in patients with chronic heart failur...
Next Document: Cardiovascular risk assessment in hypertensive patients with tests recommended by the European Guide...