| Exercise training increases size of hippocampus and improves memory. | |
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MedLine Citation:
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PMID: 21282661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hippocampus shrinks in late adulthood, leading to impaired memory and increased risk for dementia. Hippocampal and medial temporal lobe volumes are larger in higher-fit adults, and physical activity training increases hippocampal perfusion, but the extent to which aerobic exercise training can modify hippocampal volume in late adulthood remains unknown. Here we show, in a randomized controlled trial with 120 older adults, that aerobic exercise training increases the size of the anterior hippocampus, leading to improvements in spatial memory. Exercise training increased hippocampal volume by 2%, effectively reversing age-related loss in volume by 1 to 2 y. We also demonstrate that increased hippocampal volume is associated with greater serum levels of BDNF, a mediator of neurogenesis in the dentate gyrus. Hippocampal volume declined in the control group, but higher preintervention fitness partially attenuated the decline, suggesting that fitness protects against volume loss. Caudate nucleus and thalamus volumes were unaffected by the intervention. These theoretically important findings indicate that aerobic exercise training is effective at reversing hippocampal volume loss in late adulthood, which is accompanied by improved memory function. |
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Authors:
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Kirk I Erickson; Michelle W Voss; Ruchika Shaurya Prakash; Chandramallika Basak; Amanda Szabo; Laura Chaddock; Jennifer S Kim; Susie Heo; Heloisa Alves; Siobhan M White; Thomas R Wojcicki; Emily Mailey; Victoria J Vieira; Stephen A Martin; Brandt D Pence; Jeffrey A Woods; Edward McAuley; Arthur F Kramer |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2011-01-31 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 108 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-17 Completed Date: 2011-04-14 Revised Date: 2012-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 3017-22 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aging / physiology* Brain-Derived Neurotrophic Factor / blood Enzyme-Linked Immunosorbent Assay Exercise / physiology* Hippocampus / anatomy & histology*, physiology Humans Magnetic Resonance Imaging Memory / physiology* Middle Aged Organ Size Space Perception / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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P30 AG024827/AG/NIA NIH HHS; P50 AG005133/AG/NIA NIH HHS; R01 AG25032/AG/NIA NIH HHS; R01 AG25667/AG/NIA NIH HHS; R37 AG025667-07/AG/NIA NIH HHS; R37 AG025667-08/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Brain-Derived Neurotrophic Factor |
| Comments/Corrections | |
Comment In:
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Proc Natl Acad Sci U S A. 2011 May 3;108(18):E89; author reply E90
[PMID:
21504947
]
Mov Disord. 2011 Mar;26(4):607 [PMID: 21506145 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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