| Exercise training increases oxygen uptake efficiency slope in chronic heart failure. | |
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MedLine Citation:
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PMID: 18391638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIM: The oxygen uptake efficiency slope (OUES) is a novel measure of cardiopulmonary reserve. OUES is measured during an exercise test, but it is independent of the maximally achieved exercise intensity. It has a higher prognostic value in chronic heart failure (CHF) than other exercise test-derived variables such as(Equation is included in full-text article.)or(Equation is included in full-text article.)slope. Exercise training improves(Equation is included in full-text article.)and(Equation is included in full-text article.)in CHF patients. We hypothesized that exercise training also improves OUES. METHODS AND RESULTS: We studied 34 New York Heart Association (NYHA) class II-III CHF patients who constituted an exercise training group T (N=20; 19 men/1 woman; age 60+/-9 years; left ventricular ejection fraction 34+/-5%) and a control group C (N=14; 13 men/one woman; age 63+/-10 years; left ventricular ejection fraction 34+/-7%). A symptom-limited exercise test was performed at baseline and repeated after 4 weeks (C) or after completion of the training program (T). Exercise training increased NYHA class from 2.6 to 2.0 (P<0.05),(Equation is included in full-text article.)by 14% [P(TvsC)<0.01], and OUES by 19% [P(TvsC)<0.01]. Exercise training decreased(Equation is included in full-text article.)by 14% [P(TvsC)<0.05]. CONCLUSION: Exercise training improved NYHA class,(Equation is included in full-text article.)and also OUES. This finding is of great potential interest as OUES is insensitive for peak load. Follow-up studies are needed to demonstrate whether OUES improvements induced by exercise training are associated with improved prognosis. |
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Authors:
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Maaike G J Gademan; Cees A Swenne; Harriette F Verwey; Hedde van de Vooren; Joris C W Haest; Henk J van Exel; Caroline M H B Lucas; Ger V J Cleuren; Martin J Schalij; Ernst E van der Wall |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 15 ISSN: 1741-8267 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-08 Completed Date: 2008-07-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 140-4 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chronic Disease Exercise Test Exercise Therapy* Female Heart Failure / metabolism, physiopathology, rehabilitation* Humans Male Middle Aged Oxygen Consumption* Pulmonary Ventilation Severity of Illness Index Stroke Volume Treatment Outcome Ventricular Function, Left |
| Grant Support | |
ID/Acronym/Agency:
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HL078797-01A1/HL/NHLBI NIH HHS; //British Heart Foundation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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