Document Detail


Exercise training in systolic and diastolic dysfunction: effects on cardiac function, functional capacity, and quality of life.
MedLine Citation:
PMID:  17383289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Exercise training improves functional capacity in patients with systolic dysfunction (SD), but the role of exercise training in diastolic dysfunction (DD) is unclear. We compared the responses of patients with exercise intolerance and SD or DD to 16 weeks of exercise training. METHODS: Fifty-one patients with SD and DD were enrolled in exercise training, which was completed in 24 patients with SD (22 men, 62 +/- 8 years old, ejection fraction <35%) and 18 patients with DD (9 men, 65 +/- 5 years old, ejection fraction >45%). Peak VO2, quality of life (Minnesota Living with Heart Failure and Hare-Davis questionnaires), and echocardiographic measures (ejection fraction, systolic and diastolic tissue velocity, and filling pressure) were performed at baseline and after 16 weeks of training. RESULTS: Patients with SD and those with DD showed similar baseline peak VO2 (11.9 +/- 2.5 vs 12.5 +/- 4.1 mL/[kg min], P = .55) and E/E' ratio (21 +/- 13 vs 14.4 +/- 15, P = .07), but different systolic velocity (3.4 +/- 1.0 vs 5.5 +/- 1.7 cm/s, P < .001), diastolic velocity (3.9 +/- 1.5 vs 5.1 +/- 1.8 cm/s, P = .05), and ejection fraction (26 +/- 8% vs 55 +/- 9%, P < .001). Baseline quality of life scores were worse in patients with SD. There was a similar increment in peak VO2 in SD (24%, P = .001) and DD (30%, P < .001) after exercise training, but this did not correlate with improved diastolic parameters. Quality of life scores improved in both SD and DD, although SD scores remained significantly worse. CONCLUSIONS: In patients with exercise limitation attributed to DD, the improvement in peak VO2 and quality of life with exercise training is similar to those with SD, but unrelated to changes in diastolic function.
Authors:
Neil Smart; Brian Haluska; Leanne Jeffriess; Thomas H Marwick
Related Documents :
6756629 - Left ventricular function at rest, peak exercise and postexercise.
20646909 - Exercise-induced left ventricular systolic dysfunction in women heterozygous for dystro...
17875959 - Systemic peripheral vascular resistance as a determinant of functional cardiac reserve ...
11052859 - Comparison of the prognostic value of left ventricular filling and peak oxygen uptake i...
15807379 - Variations of stroking parameters associated with 200 m competitive performance improve...
8059729 - Right and left ventricular performance 10 years after mustard repair of transposition o...
20188719 - Effect of exercise training on chronic inflammation.
24149559 - Obesity-related cardiovascular risk factors after long- term resistance training and gi...
2789479 - Overuse injuries in ultraendurance triathletes.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  153     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-26     Completed Date:  2007-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  530-6     Citation Subset:  AIM; IM    
Affiliation:
University of Queensland, Brisbane, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Diastole
Exercise Therapy*
Female
Humans
Male
Middle Aged
Quality of Life*
Systole
Ventricular Dysfunction / physiopathology*,  therapy*,  ultrasonography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prognostic implication of redefining indeterminate microvolt T-wave alternans studies as abnormal or...
Next Document:  The effects of initiation or continuation of statin therapy on cholesterol level and all-cause morta...