Document Detail

Exercise training in systolic and diastolic dysfunction: effects on cardiac function, functional capacity, and quality of life.
MedLine Citation:
PMID:  17383289     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Exercise training improves functional capacity in patients with systolic dysfunction (SD), but the role of exercise training in diastolic dysfunction (DD) is unclear. We compared the responses of patients with exercise intolerance and SD or DD to 16 weeks of exercise training. METHODS: Fifty-one patients with SD and DD were enrolled in exercise training, which was completed in 24 patients with SD (22 men, 62 +/- 8 years old, ejection fraction <35%) and 18 patients with DD (9 men, 65 +/- 5 years old, ejection fraction >45%). Peak VO2, quality of life (Minnesota Living with Heart Failure and Hare-Davis questionnaires), and echocardiographic measures (ejection fraction, systolic and diastolic tissue velocity, and filling pressure) were performed at baseline and after 16 weeks of training. RESULTS: Patients with SD and those with DD showed similar baseline peak VO2 (11.9 +/- 2.5 vs 12.5 +/- 4.1 mL/[kg min], P = .55) and E/E' ratio (21 +/- 13 vs 14.4 +/- 15, P = .07), but different systolic velocity (3.4 +/- 1.0 vs 5.5 +/- 1.7 cm/s, P < .001), diastolic velocity (3.9 +/- 1.5 vs 5.1 +/- 1.8 cm/s, P = .05), and ejection fraction (26 +/- 8% vs 55 +/- 9%, P < .001). Baseline quality of life scores were worse in patients with SD. There was a similar increment in peak VO2 in SD (24%, P = .001) and DD (30%, P < .001) after exercise training, but this did not correlate with improved diastolic parameters. Quality of life scores improved in both SD and DD, although SD scores remained significantly worse. CONCLUSIONS: In patients with exercise limitation attributed to DD, the improvement in peak VO2 and quality of life with exercise training is similar to those with SD, but unrelated to changes in diastolic function.
Neil Smart; Brian Haluska; Leanne Jeffriess; Thomas H Marwick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  153     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-26     Completed Date:  2007-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  530-6     Citation Subset:  AIM; IM    
University of Queensland, Brisbane, Australia.
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MeSH Terms
Exercise Therapy*
Middle Aged
Quality of Life*
Ventricular Dysfunction / physiopathology*,  therapy*,  ultrasonography

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