Document Detail

Exercise training in older patients with systolic heart failure: adherence, exercise capacity, inflammation and glycemic control.
MedLine Citation:
PMID:  19101855     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Training improves exercise capacity in patients with heart failure (CHF) but most evidence is on selected younger patients with systolic CHF. DESIGN: All patients diagnosed with CHF over 3 years were screened for inclusion and exclusion criteria. Fifty two patients with systolic CHF (LVEF<45, NYHA II-III) received supervised exercise training twice weekly for 8 weeks. RESULTS: Mean age was 68.2 (+/-SD 11.3) years. Despite marked improvements in physical fitness (workload, 6 minute walk test, incremental shuttle walk test and sit to stand test), there were no changes in serological markers of glycemic control (glucose, insulin, glycerol, free fatty acids, HbA1c), inflammation and endothelial function (hsCRP, orosomucoid, interleukin 6, TNF-alpha, urine-orosomucoid and -albumin/creatinin), lipid metabolism, NT-proBNP or other regulatory hormones (cortisol, epinephrine and IGF-1). There were no changes in quality of life. CONCLUSIONS: The effect of exercise training in these older CHF-patients was not as impressive as reported in younger and more selected patients. More studies on the efficiency of exercise training that reflect the age- and co-morbidity of the majority of CHF-patients are needed.
Eva Prescott; Rasmus Hjardem-Hansen; Flemming Dela; Ane S Teisner; Henrik Nielsen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  43     ISSN:  1651-2006     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-24     Completed Date:  2009-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  England    
Other Details:
Languages:  eng     Pagination:  249-55     Citation Subset:  IM    
Department of Cardiology, Bispebjerg University Hospital, Copenhagen, Denmark.
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MeSH Terms
Age Factors
Aged, 80 and over
Biological Markers / blood
Blood Glucose / metabolism
Endothelium, Vascular / metabolism
Exercise Therapy*
Exercise Tolerance*
Feasibility Studies
Heart Failure, Systolic / blood,  physiopathology,  therapy*
Hemoglobin A, Glycosylated / metabolism
Inflammation / blood,  physiopathology,  therapy*
Inflammation Mediators / blood*
Insulin / blood
Insulin Resistance*
Middle Aged
Patient Compliance*
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Inflammation Mediators; 0/hemoglobin A1c protein, human; 11061-68-0/Insulin

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