| Exercise training in mitochondrial myopathy: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 15962332 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with mitochondrial myopathies (MM) usually suffer from exercise intolerance due to their impaired oxidative capacity and physical deconditioning. We evaluated the effects of a 12-week supervised randomized rehabilitation program involving endurance training in patients with MM. Twenty MM patients were assigned to a training or control group. For three nonconsecutive days each week, patients combined cycle exercise at 70% of their peak work rate with three upper-body weight-lifting exercises performed at 50% of maximum capacity. Training increased maximal oxygen uptake (28.5%), work output (15.5%), and minute ventilation (40%), endurance performance (62%), walking distance in shuttle walking test (+95 m), and peripheral muscle strength (32%-62%), and improved Nottingham Health Profile scores (21.47%) and clinical symptoms. Control MM patients did not change from baseline. Results show that our exercise program is an adequate training strategy for patients with mitochondrial myopathy. |
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Authors:
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Pilar Cejudo; Juan Bautista; Teodoro Montemayor; Rafael Villagómez; Luis Jiménez; Francisco Ortega; Yolanda Campos; Hildegard Sánchez; Joaquín Arenas |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Muscle & nerve Volume: 32 ISSN: 0148-639X ISO Abbreviation: Muscle Nerve Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-29 Completed Date: 2005-09-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 342-50 Citation Subset: IM |
Affiliation:
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Chest Department, Hospital Universitario Virgen del Rocío, 41013 Seville, Spain. pilarcejudo@terra.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Exercise / physiology* Exercise Therapy / methods* Exercise Tolerance / physiology* Female Humans Lactic Acid / blood Male Maximal Voluntary Ventilation / physiology Middle Aged Mitochondrial Myopathies / physiopathology, therapy* Muscle Weakness / physiopathology, therapy* Muscle, Skeletal / physiology Oxygen Consumption / physiology Physical Fitness / physiology* Quality of Life Questionnaires Recovery of Function / physiology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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