| Exercise training in mild hypertension: effects on blood pressure, left ventricular mass and coagulation factor VII and fibrinogen. | |
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MedLine Citation:
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PMID: 9286510 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to assess the effects of aerobic exercise on resting and 24-hour blood pressure (BP), left ventricular mass (LVM), plasma fibrinogen and factor VII (FVII). For this purpose 14 sedentary subjects with untreated diastolic BP between 90 and 104 mm Hg completed a 12-week supervised exercise program. At the end of this period, 8 subjects resumed a sedentary life-style and were reexamined 2 months later (detraining). Baseline, posttraining and postdetraining examinations included resting BP assessment, ambulatory BP monitoring, cardiopulmonary stress test, echocardiography and measurements of plasma fibrinogen and FVII. Exercise-mediated increase in aerobic fitness (VO2 max + 24%) was associated with a significant reduction in resting systolic and diastolic BP (p < 0.01), mean systolic and diastolic 24-hour BP (p < 0.001) and LVM index. As for the coagulation parameters only the concentration of fibrinogen significantly decreased (p < 0.01) whereas FVII remained unchanged. The 8 subjects that resumed a sedentary life-style were reexamined 2 months later: their resting BP, 24-hour BP and fibrinogen concentration returned to baseline values; only the effect on LVM was conserved. Our study underlines the usefulness and safety of regular physical exercise in mild hypertension. Most of the patients (11 of 14) had their BP normalized and a significant reduction in LVM and fibrinogen concentration was observed, leading to an overall improvement in coronary risk profile. |
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Authors:
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R Zanettini; D Bettega; O Agostoni; B Ballestra; G del Rosso; R di Michele; P M Mannucci |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiology Volume: 88 ISSN: 0008-6312 ISO Abbreviation: Cardiology Publication Date: 1997 Sep-Oct |
Date Detail:
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Created Date: 1997-10-14 Completed Date: 1997-10-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 468-73 Citation Subset: IM |
Affiliation:
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Cardiac Rehabilitation Unit, University of Milan, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Coagulation Tests Blood Pressure / physiology* Body Mass Index Echocardiography Exercise Therapy* Factor VII / physiology* Female Fibrinogen / physiology* Humans Hypertension / blood, physiopathology, therapy* Male Middle Aged Physical Fitness Ventricular Function, Left / physiology* |
| Chemical | |
Reg. No./Substance:
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9001-25-6/Factor VII; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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