Document Detail

Exercise training in juvenile dermatomyositis.
MedLine Citation:
PMID:  22505288     Owner:  NLM     Status:  Publisher    
Objective: To investigate the effects of a supervised exercise training program on health parameters, physical capacity, and health-related quality of life in patients with mild and chronic juvenile dermatomyositis (JDM). Methods: This was a prospective longitudinal study following 10 children with mild and chronic JDM (disease duration > 1 year). The exercise program consisted of a twice-a-week aerobic and resistance training. At baseline and after the 12-week intervention, we assessed muscle strength and function, aerobic conditioning, body composition, JDM scores, and health-related quality of life. Results: Child self-report and parent proxy-report PedsQL scores were improved after the intervention (-40.3%, p=0.001 and -48.2%, p=0.049, respectively). Importantly, after exercise DAS was reduced (-26.9%, p=0.026) and CMAS was improved (+2.5%, p=0.009), whereas MMT presented a trend towards statistical significance (+2.2%, p=0.081). The V02peak and time-to-exhaustion were increased by 13.3% (p=0.001) and 18.2% (p=0.003), respectively, whereas resting heart-rate was decreased by 14.7% (p=0.006), indicating important cardiovascular adaptations to the exercise program. Upper- and lower-limb muscle strength and muscle function were also significantly improved after the exercise training (p<0.05). Both the whole body and the lumbar spine bone mineral apparent density were significantly increased after training (1.44%, p=0.044 and 2.85%, p=0.008, respectively). Conclusions: We showed for the first time that a 12-week supervised exercise program is safe and can improve muscle strength and function, aerobic conditioning, bone mass, disease activity, and health-related quality of life in patients with active and non-active mild and chronic JDM with near normal physical function and quality of life. © 2012 by the American College of Rheumatology.
Clarissa Harumi Omori; Clovis Artur Almeida Silva; Adriana Maluf Elias Sallum; Rosa Maria Rodrigues Pereira; Ana Lúcia Sá-Pinto; Hamilton Roschel; Bruno Gualano
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-13
Journal Detail:
Title:  Arthritis care & research     Volume:  -     ISSN:  2151-4658     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 by the American College of Rheumatology.
Pediatric Rheumatology Unit, Children's Institute, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
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