| Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle. | |
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MedLine Citation:
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PMID: 16079649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Chronic heart failure (CHF) is accompanied by an inflammatory activation which occurs both systemically and in the skeletal muscle. Exercise training has been shown to reduce the local expression of cytokines and inducible nitric oxide synthase (iNOS) in muscle biopsies of CHF patients. INOS-derived NO can inhibit oxidative phosphorylation and contribute to skeletal muscle dysfunction in CHF. DESIGN: To investigate the correlation between changes in local iNOS expression associated with regular exercise and changes in aerobic enzyme activities in the skeletal muscle of patients with CHF. Twenty male CHF patients [ejection fraction 25% (SE 2), age 54 (SE 2) years] were randomized to a training (n=10) or a control group (C, n=10). METHODS: At baseline and after 6 months skeletal muscle iNOS expression was measured by real-time polymerase chain reaction. INOS protein and protein nitrosylation were assessed by immunohistochemistry. Cytochrome c oxidase (COX) activity was quantified electrochemically using the Clark oxygen electrode. RESULTS: Exercise training led to a 27% increase in cytochrome c oxidase activity [from 21.8 (SE 3.2) to 27.7 (SE 3.5) nmol O2/mg per min, P=0.02 versus baseline]. Changes in iNOS expression and iNOS protein content were inversely correlated with changes in COX-activity (r=-0.60, P=0.01; r=-0.71, P<0.001). CONCLUSIONS: The inverse correlation between iNOS expression/iNOS protein content and COX-activity indicates that local anti-inflammatory effects may contribute to improved muscular oxidative metabolism. |
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Authors:
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Stephan Gielen; Volker Adams; Axel Linke; Sandra Erbs; Sven Möbius-Winkler; Andreas Schubert; Gerhard Schuler; Rainer Hambrecht |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 12 ISSN: 1741-8267 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-04 Completed Date: 2006-07-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 393-400 Citation Subset: IM |
Affiliation:
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Universität Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin/Kardiologie, Leipzig, Germany. hamr@medizin.uni-leipzig.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chronic Disease Electron Transport Complex IV / metabolism Energy Metabolism Exercise* Exercise Test Exercise Tolerance Follow-Up Studies Heart Failure / metabolism, physiopathology* Humans Immunohistochemistry Male Middle Aged Muscle, Skeletal / metabolism*, physiopathology Nitric Oxide Synthase Type II / biosynthesis Oxidative Stress Oxygen Consumption Prospective Studies Tyrosine / analogs & derivatives, metabolism |
| Chemical | |
Reg. No./Substance:
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3604-79-3/3-nitrotyrosine; 55520-40-6/Tyrosine; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.9.3.1/Electron Transport Complex IV |
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