Document Detail


Exercise training improves physical fitness and vascular function in children with type 1 diabetes.
MedLine Citation:
PMID:  21226819     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Children with diabetes mellitus type 1 (DM1) demonstrate endothelial dysfunction and mild artery wall thickening compared to their age-matched healthy peers. In this study, we examined the effect of 18-week exercise training on physical fitness, and vascular function and structure in children with DM1. We examined physical fitness, brachial artery endothelial function (flow-mediated dilation (FMD)) and common carotid artery diameter, wall thickness and wall-to-lumen ratio before and after 18-week exercise training in children with DM1 (n=7). Physical fitness, measured as maximal oxygen consumption, improved after training (P=0.039). Brachial artery FMD improved from 7.5±4.2 to 12.4±5.2 (P=0.038). Carotid artery diameter, wall thickness and wall-to-lumen ratio did not change significantly (P=0.26, 0.53 and 0.27, respectively). We demonstrated that exercise training in children with DM1 effectively reverses endothelial dysfunction and improves physical fitness. These data emphasize the important role for physical activity in the management of DM1.
Authors:
J P H Seeger; D H J Thijssen; K Noordam; M E C Cranen; M T E Hopman; M W G Nijhuis-van der Sanden
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-12
Journal Detail:
Title:  Diabetes, obesity & metabolism     Volume:  -     ISSN:  1463-1326     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883645     Medline TA:  Diabetes Obes Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Affiliation:
Departments of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands Departments of Paediatric Physical Therapy, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands Departments of Scientific Institute for Quality of Healthcare Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands Departments of Paediatrics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands Department of Physiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein-noord 21, 6500 HB Nijmegen, the Netherlands Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom.
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