| Exercise training improves muscle vasodilatation in individuals with T786C polymorphism of endothelial nitric oxide synthase gene. | |
| | |
MedLine Citation:
|
PMID: 20605946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Allele T at promoter region of the eNOS gene has been associated with an increase in coronary disease mortality, suggesting that this allele increases susceptibility for endothelial dysfunction. In contrast, exercise training improves endothelial function. Thus, we hypothesized that: 1) Muscle vasodilatation during exercise is attenuated in individuals homozygous for allele T, and 2) Exercise training improves muscle vasodilatation in response to exercise for TT genotype individuals. From 133 preselected healthy individuals genotyped for the T786C polymorphism, 72 participated in the study: TT (n = 37; age 27 ± 1 yr) and CT+CC (n = 35; age 26 ± 1 yr). Forearm blood flow (venous occlusion plethysmography) and blood pressure (oscillometric automatic cuff) were evaluated at rest and during 30% handgrip exercise. Exercise training consisted of three sessions per week for 18 wk, with intensity between anaerobic threshold and respiratory compensation point. Resting forearm vascular conductance (FVC, P = 0.17) and mean blood pressure (P = 0.70) were similar between groups. However, FVC responses during handgrip exercise were significantly lower in TT individuals compared with CT+CC individuals (0.39 ± 0.12 vs. 1.08 ± 0.27 units, P = 0.01). Exercise training significantly increased peak VO(2) in both groups, but resting FVC remained unchanged. This intervention significantly increased FVC response to handgrip exercise in TT individuals (P = 0.03), but not in CT+CC individuals (P = 0.49), leading to an equivalent FVC response between TT and CT+CC individuals (1.05 ± 0.18 vs. 1.59 ± 0.27 units, P = 0.27). In conclusion, exercise training improves muscle vasodilatation in response to exercise in TT genotype individuals, demonstrating that genetic variants influence the effects of interventions such as exercise training. |
| | |
Authors:
|
Marcelo V Negrao; Cleber R Alves; Guilherme B Alves; Alexandre C Pereira; Rodrigo G Dias; Mateus C Laterza; Gloria F Mota; Edilamar M Oliveira; Vinícius Bassaneze; Jose E Krieger; Carlos E Negrao; Maria Urbana P B Rondon |
Related Documents
:
|
12002416 - Biochemical parameters of endothelial dysfunction in cardiological syndrome x. 12519086 - Effects of inhibition of atp-sensitive potassium channels on metabolic vasodilation in ... 12070196 - Elevation in resting blood flow attenuates exercise hyperemia. 11527646 - The effect of combined aerobic and resistance exercise training on vascular function in... 17063066 - Comparison of exercise models in an elderly population. 19767796 - The effects of increased endurance training load on biomarkers of heat intolerance duri... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-06 |
Journal Detail:
|
Title: Physiological genomics Volume: 42A ISSN: 1531-2267 ISO Abbreviation: Physiol. Genomics Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-20 Completed Date: 2010-12-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9815683 Medline TA: Physiol Genomics Country: United States |
Other Details:
|
Languages: eng Pagination: 71-7 Citation Subset: IM |
Affiliation:
|
Heart Institute (InCor), University of São Paulo Medical School, Cerqueira César, São Paulo, SP, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Exercise / physiology* Female Genotype Heart Rate / genetics, physiology Humans Male Muscle, Skeletal / blood supply* Nitric Oxide Synthase Type III / genetics* Vasodilation / genetics, physiology* Young Adult |
| Chemical | |
Reg. No./Substance:
|
EC 1.14.13.39/Nitric Oxide Synthase Type III |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Is there a sex ratio difference in the familial aggregation of specific language impairment? A meta ...
Next Document: Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storag...