Document Detail


Exercise training improves lipoprotein lipid profiles in patients with coronary artery disease.
MedLine Citation:
PMID:  6858834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of endurance exercise training on plasma lipoprotein lipids were determined in 10 men, ages 46 to 62 years, with coronary artery disease (CAD). Patients maintained body weight, health-related behaviors, and stable diets throughout the program. Training was at 50% to 85% of maximal oxygen consumption (VO2 max) for 40 to 60 minutes, 3 to 5 days/week for 29 +/- 7 weeks. Training increased VO2 max (31 +/- 19%, p less than 0.001), reduced plasma cholesterol (C) (-8 +/- 4%, p less than 0.01), low-density lipoprotein-C (LDL-C) (-9 +/- 9%, p less than 0.01), and triglyceride (TG) (-13 +/- 32%, p less than 0.05) concentrations, and increased high-density lipoprotein-C (HDL-C) levels (11 +/- 13%, p less than 0.05) and HDL-C/LDL-C ratios (25 +/- 20%, p less than 0.01). Changes in LDL-C and VO2 max were correlated (r = -0.73, p +/- 0.01), while the changes in LDL-C and HDL-C each correlated inversely with pretraining lipoprotein levels (rLDL-C = -0.77, p less than 0.01; rHDL-C = -0.68, p less than 0.05). Thus potentially "antiatherogenic" benefits of exercise seem to be due to a training effect, since they correlate best with changes in VO2 max and are maximal in patients with initially low VO2 max, high LDL-C, and low HDL-C levels.
Authors:
G W Heath; A A Ehsani; J M Hagberg; J M Hinderliter; A P Goldberg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  105     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  889-95     Citation Subset:  AIM; IM; S    
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MeSH Terms
Descriptor/Qualifier:
Cholesterol / blood
Cholesterol, HDL
Cholesterol, LDL
Coronary Disease / blood*,  physiopathology
Humans
Lipids / blood*
Lipoproteins / blood*
Lipoproteins, HDL / blood
Lipoproteins, LDL / blood
Male
Middle Aged
Oxygen / physiology
Physical Exertion
Physical Fitness*
Respiration
Triglycerides / blood
Grant Support
ID/Acronym/Agency:
HL07081/HL/NHLBI NIH HHS; HL22215/HL/NHLBI NIH HHS; N01-HV2-29162/HV/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 0/Lipoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Triglycerides; 57-88-5/Cholesterol; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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