Document Detail


Exercise training improves hemodynamic recovery to isometric exercise in obese men with type 2 diabetes but not in obese women.
MedLine Citation:
PMID:  22902004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Women with type 2 diabetes (T2D) show greater rates of mortality due to ischemic heart disease than men with T2D. We aimed to examine cardiovascular and autonomic function responses to isometric handgrip (IHG) exercise between men and women with T2D, before and after an exercise training program.
MATERIALS/METHODS: Hemodynamic responses were measured in 22 men and women with T2D during and following a 3-min IHG test, and before and after 16 wks of aerobic exercise training.
RESULTS: Women had a smaller decrease in mean arterial pressure (MAP) and systolic blood pressure (BP) during recovery from IHG (ΔMAP(REC)) than men pre- and post-training (P<0.05). Men showed a greater reduction in diastolic BP during recovery from IHG (P<0.05), and exercise training improved this response in men but not in women (men, pre-training: -13.9±1.8, post-training: -20.5±5.3 mmHg vs. women, pre-training: -10.7±1.7, post-training: -4.1±4.9 mmHg; P<0.05). Men had a greater reduction in sympathetic modulation of vasomotor tone (P<0.05), as estimated by blood pressure variability, following IHG. This response was accentuated after training, while this training effect was not seen in women. Post-training ΔMAP(REC) was correlated with recovery of low frequency component of the BP spectrum (ΔLF(SBPrec), r=0.52, P<0.05).
CONCLUSIONS: Differences in BP recovery immediately following IHG may be attributed to gender differences in cardiovascular autonomic modulation. An improvement in these responses occurs following aerobic exercise training in obese men, but not in obese women with T2D which reflects a better adaptive autonomic response to exercise training.
Authors:
Jill A Kanaley; Styliani Goulopoulou; Ruth Franklin; Tracy Baynard; Robert L Carhart; Ruth S Weinstock; Bo Fernhall
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-08-15
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  61     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-23     Completed Date:  2013-01-23     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1739-46     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antihypertensive Agents / administration & dosage
Arterial Pressure
Baroreflex
Blood Pressure*
Diabetes Mellitus, Type 2 / complications,  physiopathology*
Exercise*
Glucose Tolerance Test
Hand Strength*
Heart Rate*
Hemoglobin A, Glycosylated / metabolism
Humans
Hypoglycemic Agents / administration & dosage
Hypolipidemic Agents / administration & dosage
Isometric Contraction*
Male
Middle Aged
Obesity / complications,  physiopathology*
Oxygen Consumption
Sex Factors
Grant Support
ID/Acronym/Agency:
R21 DK063179/DK/NIDDK NIH HHS; R21DK063179/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 0/Hypolipidemic Agents; 0/hemoglobin A1c protein, human
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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