Document Detail

Exercise training improves functional post-ischemic recovery in senescent heart.
MedLine Citation:
PMID:  18984034     Owner:  NLM     Status:  MEDLINE    
The incidence of ischemic cardiac diseases increases with age and elderly subjects are more vulnerable to myocardial infarction. Endurance exercise (e.g. treadmill training) provides cardioprotection against an ischemia and reperfusion (IR) event in adult heart but such a potential beneficial effect of regular exercise has never been evaluated during aging. Therefore, this study investigated the effects of moderate running training on post-ischemic recovery of contractile function and coronary perfusion in senescent myocardium. Isolated hearts of sedentary (24 mo-sedentary; n=10) and trained senescent (24 mo-trained; n=11; moderate running: 1h/day, 5 days/week for 12 weeks) rats were submitted to 45min low-flow ischemia (15% of initial coronary flow (CF)) followed by 30min reperfusion. Active tension (AT) and CF were recorded at baseline and after 1, 3, 5, 10, 15, 20, 25 and 30min of reperfusion. Left ventricular protein carbonylation, and both heat-shock-protein 70 (HSP70) and endothelial nitric oxide synthase (eNOS) contents were determined by Oxyblotting and Western blotting, respectively. Regular physical exercise improves impairment of functional post-ischemic recovery (AT and CF) of aged hearts during reperfusion and this cardioprotection is associated to limited protein oxidation and increased HSP70 and eNOS myocardial contents.
Christine Le Page; Philippe Noirez; Jos? Courty; Bruno Riou; Bernard Swynghedauw; Sophie Besse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-17
Journal Detail:
Title:  Experimental gerontology     Volume:  44     ISSN:  1873-6815     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-16     Completed Date:  2010-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  177-82     Citation Subset:  IM    
Laboratoire Croissance cellulaire, R?paration et R?g?n?ration Tissulaires, UMR CNRS 7149, Facult? des Sciences et Techniques, Universit? Paris Est, Cr?teil, France.
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MeSH Terms
Aging / physiology*
Analysis of Variance
Blotting, Western
Citrate (si)-Synthase / metabolism
Coronary Circulation / physiology
HSP70 Heat-Shock Proteins / metabolism
Muscle, Skeletal / metabolism
Myocardial Contraction / physiology
Myocardial Ischemia / metabolism*,  physiopathology
Myocardial Reperfusion Injury / metabolism,  prevention & control*
Myocardium / metabolism
Nitric Oxide Synthase Type III / metabolism
Oxidative Stress*
Physical Conditioning, Animal / physiology*
Protein Carbonylation
Rats, Wistar
Reg. No./Substance:
0/HSP70 Heat-Shock Proteins; EC Oxide Synthase Type III; EC (si)-Synthase

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