| Exercise training improves functional post-ischemic recovery in senescent heart. | |
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MedLine Citation:
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PMID: 18984034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incidence of ischemic cardiac diseases increases with age and elderly subjects are more vulnerable to myocardial infarction. Endurance exercise (e.g. treadmill training) provides cardioprotection against an ischemia and reperfusion (IR) event in adult heart but such a potential beneficial effect of regular exercise has never been evaluated during aging. Therefore, this study investigated the effects of moderate running training on post-ischemic recovery of contractile function and coronary perfusion in senescent myocardium. Isolated hearts of sedentary (24 mo-sedentary; n=10) and trained senescent (24 mo-trained; n=11; moderate running: 1h/day, 5 days/week for 12 weeks) rats were submitted to 45min low-flow ischemia (15% of initial coronary flow (CF)) followed by 30min reperfusion. Active tension (AT) and CF were recorded at baseline and after 1, 3, 5, 10, 15, 20, 25 and 30min of reperfusion. Left ventricular protein carbonylation, and both heat-shock-protein 70 (HSP70) and endothelial nitric oxide synthase (eNOS) contents were determined by Oxyblotting and Western blotting, respectively. Regular physical exercise improves impairment of functional post-ischemic recovery (AT and CF) of aged hearts during reperfusion and this cardioprotection is associated to limited protein oxidation and increased HSP70 and eNOS myocardial contents. |
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Authors:
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Christine Le Page; Philippe Noirez; Jos? Courty; Bruno Riou; Bernard Swynghedauw; Sophie Besse |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-17 |
Journal Detail:
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Title: Experimental gerontology Volume: 44 ISSN: 1873-6815 ISO Abbreviation: Exp. Gerontol. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-16 Completed Date: 2010-02-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: England |
Other Details:
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Languages: eng Pagination: 177-82 Citation Subset: IM |
Affiliation:
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Laboratoire Croissance cellulaire, R?paration et R?g?n?ration Tissulaires, UMR CNRS 7149, Facult? des Sciences et Techniques, Universit? Paris Est, Cr?teil, France. Christine.Le-Page@univ-paris5.fr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aging / physiology* Analysis of Variance Animals Blotting, Western Citrate (si)-Synthase / metabolism Coronary Circulation / physiology Exercise HSP70 Heat-Shock Proteins / metabolism Humans Male Muscle, Skeletal / metabolism Myocardial Contraction / physiology Myocardial Ischemia / metabolism*, physiopathology Myocardial Reperfusion Injury / metabolism, prevention & control* Myocardium / metabolism Nitric Oxide Synthase Type III / metabolism Oxidative Stress* Perfusion Physical Conditioning, Animal / physiology* Protein Carbonylation Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/HSP70 Heat-Shock Proteins; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 2.3.3.1/Citrate (si)-Synthase |
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