| Exercise training improves cardiac function and attenuates arrhythmia in CPVT mice. | |
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MedLine Citation:
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PMID: 23042908 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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CPVT is a lethal ventricular arrhythmia evoked by physical or emotional stress. Recessively inherited CPVT is caused by either missense or null-allele mutations in the cardiac calsequestrin (CASQ2) gene. It was suggested that defects in CASQ2 cause protein deficiency, impair Ca(2+) uptake to the sarcoplasmic reticulum and Ca(2+)-dependent inhibition of ryanodine channels, leading to diastolic Ca(2+) leak, after-depolarizations and arrhythmia. To examine the effect of exercise training on left ventricular remodeling and arrhythmia, CASQ2 knockout (KO) mice and wild-type controls underwent echocardiography and heart rhythm telemetry before and after 6 weeks of training by treadmill exercise. RT-PCR and Western blotting were used to measure gene and protein expression. Left ventricular fractional shortening was impaired in KO (35±3% vs 41±8% in controls, p<0.05) and improved after training (44±5% and 51±3 in KO and control mice, respectively, p=NS). The exercise tolerance was low in KO mice (16±1 min vs 29±2 in controls, p<0.01) but improved in trained animals (26±2 vs 30±3 min, respectively, p=NS). The hearts of KO mice had a higher basal expression of the BNP gene. After training the expression of natriuretic peptide genes markedly decreased with no difference between KO and controls. Exercise training was not associated with a change in VT prevalence but appeared to reduce arrhythmia load as manifested by a decrease in ventricular beats during stress. We conclude that in KO mice, which recapitulate the phenotype of human CPVT2, exercise training is well tolerated and could offer a strategy for heart conditioning against stress-induced arrhythmia. |
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Authors:
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Efrat Kurtzwald Josefson; Edith Hochhauser; Guy Katz; Eyal Porat; Jonathan G Seidman; Christine E Seidman; Yelena Chepurko; Asher Shainberg; Michael Eldar; Michael Arad |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-4 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Tel Aviv University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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