| Exercise training improves basal blood glucose metabolism with no changes of cytosolic IKK, JNK activation in skeletal muscle of OLETF rat. | |
| | |
MedLine Citation:
|
PMID: 21527545 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Redox-sensitive stress kinases and heat shock protein 72 (HSP72) have been considered to be associated with the development of type 2 diabetes in skeletal muscle. However, the effect of exercise training in skeletal muscle of type 2 diabetic models is largely unknown. The purpose of this study was to investigate the effect of 12-week exercise training, in gastrocnemius of type 2 diabetic rats, on the activation of c-Jun N-terminal Kinase (JNK), nuclear factor kappa B (NF-κB) pathway, and HSP72. Total hydroperoxide and 4-hydroxynoneal (4-HNE), as oxidative stress markers, were also examined. The Otsuka Long-Evans Tokushima fatty (OLEFT) rats were randomly divided into an exercise training group (Ex-OLETF, n=8) and a sedentary group (Sed-OLETF, n=8), while the Long-Evans Tokushima Otsuka (LETO) rats were used as a control group (Con-LETO, n=5). The Ex-OLETF rats were trained on a treadmill 5 times a week for 12 weeks. The levels of hydroperoxide and 4-HNE in both Ex-OLETF and Sed-OLETF were significantly higher compared with Con-LETO, but there was no difference between Ex-OLETF and Sed-OLETF. IκB kinase (IKK), JNK activation, and p65 nuclear translocation followed a similar pattern observed in oxidative stress markers. The level of HSP72 in Ex-OLETF was increased by exercise training, but it did not reach the level observed in Con-LETO. NF-κB DNA binding activity in Sed-OLETF was significantly higher compared with Con-LETO. Although it was not statistically significant, exercise training in Ex-OLETF showed the trend of reducing the activation of NF-κB DNA binding activity compared with Sed-OLETF (p=.104). Our findings indicate that exercise training improves basal glucose metabolism without the change of stress kinases, and that nuclear regulation of NF-κB activity in diabetic muscle could be regulated independent of the cytosolic pathway. Our study also suggests a possibility that exercise-induced HSP72 serves as a protective mechanism in skeletal muscle of OLETF rats. |
| | |
Authors:
|
Hojun Lee; Hyukki Chang; Jae-Young Park; Si-Young Kim; Kyung-Mook Choi; Wook Song |
Related Documents
:
|
16856355 - Blood lactate responses to leg presses performed against inertial resistance. 672545 - The effect of weight lifting exercise on heart rate and metabolism in experienced weigh... 2747135 - Influence of peripheral arterial occlusive disease on muscular metabolism. part 1: chan... 10066705 - African runners exhibit greater fatigue resistance, lower lactate accumulation, and hig... 2124975 - Late recurrent ischemia in infarct patients with a normal predischarge exercise test af... 16007285 - Comparison of sweat rate during graded exercise and the local rate induced by pilocarpine. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-28 |
Journal Detail:
|
Title: Experimental physiology Volume: - ISSN: 1469-445X ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1 Institute of Sports Science, Health & Exercise Science Lab, Seoul National University, Seoul, Korea; |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hydrogen sulfide: Its production and functions.
Next Document: Hepatobiliary infections due to non-capsulated Haemophilus influenzae: A case series and review of l...