Document Detail

Exercise training improves autonomic profiles in patients with Charcot-Marie-Tooth disease.
MedLine Citation:
PMID:  22006687     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: The effect of an interval exercise training (ITE) program on heart rate variability (HRV) was studied in 8 patients with Charcot-Marie-Tooth (CMT) disease and 8 healthy controls.
METHODS: At baseline, all subjects underwent ambulatory 24-hour Holter electrocardiographic (ECG) monitoring to evaluate HRV. HRV analysis was repeated on CMT patients after they completed a 24-week ITE program on a cycle ergometer.
RESULTS: Before exercise, all HRV indices were lower in patients compared with controls, and the difference reached statistical significance for pNN50 (percent of differences between adjacent R-R intervals exceeding 50 ms). After ITE, time- and frequency-domain indices were significantly improved, particularly at night (+8% mean R-R interval, +95% pNN50, 52% reduction in low/high-frequency ratio). We observed significant increases in some of the time and frequency parameters, and values sometimes exceeded those of controls at baseline.
CONCLUSIONS: Our results suggest that ITE improves HRV modulation in CMT patients by enhancing parasympathetic activity. Muscle Nerve, 2011.
Lhassan El Mhandi; Vincent Pichot; Paul Calmels; Vincent Gautheron; Frédéric Roche; Léonard Féasson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  44     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  732-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Exercise Physiology Laboratory, EA 4338, Jean Monnet University, Saint-Etienne, France; Department of Physical Medicine and Rehabilitation, University Hospital Center, Saint-Etienne, France.
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