| Exercise training improves autonomic profiles in patients with Charcot-Marie-Tooth disease. | |
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MedLine Citation:
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PMID: 22006687 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: The effect of an interval exercise training (ITE) program on heart rate variability (HRV) was studied in 8 patients with Charcot-Marie-Tooth (CMT) disease and 8 healthy controls. METHODS: At baseline, all subjects underwent ambulatory 24-hour Holter electrocardiographic (ECG) monitoring to evaluate HRV. HRV analysis was repeated on CMT patients after they completed a 24-week ITE program on a cycle ergometer. RESULTS: Before exercise, all HRV indices were lower in patients compared with controls, and the difference reached statistical significance for pNN50 (percent of differences between adjacent R-R intervals exceeding 50 ms). After ITE, time- and frequency-domain indices were significantly improved, particularly at night (+8% mean R-R interval, +95% pNN50, 52% reduction in low/high-frequency ratio). We observed significant increases in some of the time and frequency parameters, and values sometimes exceeded those of controls at baseline. CONCLUSIONS: Our results suggest that ITE improves HRV modulation in CMT patients by enhancing parasympathetic activity. Muscle Nerve, 2011. |
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Authors:
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Lhassan El Mhandi; Vincent Pichot; Paul Calmels; Vincent Gautheron; Frédéric Roche; Léonard Féasson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Muscle & nerve Volume: 44 ISSN: 1097-4598 ISO Abbreviation: Muscle Nerve Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 732-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Exercise Physiology Laboratory, EA 4338, Jean Monnet University, Saint-Etienne, France; Department of Physical Medicine and Rehabilitation, University Hospital Center, Saint-Etienne, France. l.elmhandi@univ-st-etienne.fr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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