Document Detail

Exercise training improves acetylcholine-induced endothelium-dependent hyperpolarization in type 2 diabetic rats, Otsuka Long-Evans Tokushima fatty rats.
MedLine Citation:
PMID:  11947901     Owner:  NLM     Status:  MEDLINE    
We investigated whether endothelium-derived relaxing (EDRF) and hyperpolarizing factor (EDHF) is impaired in type 2 diabetic rats (Otsuka Long-Evans Tokushima Fatty (OLETF) rat) and whether the exercise training improves impaired EDRF and EDHF. Diabetic rats were divided into the sedentary and exercise-trained groups at the age of 16 weeks. Long-Evans Tokushima Otsuka (LETO) rats were used as age-matched non-diabetic controls. EDRF as well as EDHF induced by acetylcholine in the presence of indomethacine and L-nitro N-arginine was significantly attenuated in the diabetic rats, and was further impaired with age. Exercise training significantly improved it. Both insulin resistance and abdominal fat accumulation were significantly greater in the diabetic rats, compared with the non-diabetic rats, but were decreased in exercise-trained rats. Urinary NO(2) secretion was decrease in the diabetic rats at each age, and it was improved by exercise training. The results of the study indicated that exercise training prevented impairment of EDHF, as well as EDRF in type 2 diabetic rats, presumably due to improvement of hyperglycemia and insulin resistance and increase in the production of nitric oxide by exercise training.
Asako Minami; Noriko Ishimura; Nagakatsu Harada; Sadaichi Sakamoto; Yasuharu Niwa; Yutaka Nakaya
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  162     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-04-11     Completed Date:  2002-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  85-92     Citation Subset:  IM    
Department of Nutrition, School of Medicine, University of Tokushima, 3-18-15, Kuramoto-cho, Tokushima 770-8503, Japan.
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MeSH Terms
Acetylcholine / pharmacology*
Age Factors
Aorta, Abdominal / metabolism
Aorta, Thoracic / metabolism
Biological Factors / physiology*
Blood Glucose / analysis
Body Weight / physiology
Diabetes Mellitus, Type 2 / physiopathology,  therapy*
Disease Models, Animal
Eating / physiology
Endothelium, Vascular / drug effects,  physiology
Exercise Therapy*
Histamine / pharmacology
Lipids / blood
Muscle Relaxation / drug effects
Nitric Oxide / physiology*,  urine
RNA, Messenger / biosynthesis
Rats, Inbred OLETF
Transforming Growth Factor beta / biosynthesis
Transforming Growth Factor beta1
Treatment Outcome
Vasodilator Agents / pharmacology*
Reg. No./Substance:
0/Biological Factors; 0/Blood Glucose; 0/Lipids; 0/RNA, Messenger; 0/Tgfb1 protein, rat; 0/Transforming Growth Factor beta; 0/Transforming Growth Factor beta1; 0/Vasodilator Agents; 0/endothelium-dependent hyperpolarization factor; 10102-43-9/Nitric Oxide; 51-45-6/Histamine; 51-84-3/Acetylcholine

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