| Exercise training improves acetylcholine-induced endothelium-dependent hyperpolarization in type 2 diabetic rats, Otsuka Long-Evans Tokushima fatty rats. | |
| | |
MedLine Citation:
|
PMID: 11947901 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We investigated whether endothelium-derived relaxing (EDRF) and hyperpolarizing factor (EDHF) is impaired in type 2 diabetic rats (Otsuka Long-Evans Tokushima Fatty (OLETF) rat) and whether the exercise training improves impaired EDRF and EDHF. Diabetic rats were divided into the sedentary and exercise-trained groups at the age of 16 weeks. Long-Evans Tokushima Otsuka (LETO) rats were used as age-matched non-diabetic controls. EDRF as well as EDHF induced by acetylcholine in the presence of indomethacine and L-nitro N-arginine was significantly attenuated in the diabetic rats, and was further impaired with age. Exercise training significantly improved it. Both insulin resistance and abdominal fat accumulation were significantly greater in the diabetic rats, compared with the non-diabetic rats, but were decreased in exercise-trained rats. Urinary NO(2) secretion was decrease in the diabetic rats at each age, and it was improved by exercise training. The results of the study indicated that exercise training prevented impairment of EDHF, as well as EDRF in type 2 diabetic rats, presumably due to improvement of hyperglycemia and insulin resistance and increase in the production of nitric oxide by exercise training. |
| | |
Authors:
|
Asako Minami; Noriko Ishimura; Nagakatsu Harada; Sadaichi Sakamoto; Yasuharu Niwa; Yutaka Nakaya |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Atherosclerosis Volume: 162 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 2002 May |
Date Detail:
|
Created Date: 2002-04-11 Completed Date: 2002-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
|
Languages: eng Pagination: 85-92 Citation Subset: IM |
Affiliation:
|
Department of Nutrition, School of Medicine, University of Tokushima, 3-18-15, Kuramoto-cho, Tokushima 770-8503, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholine
/
pharmacology* Age Factors Animals Aorta, Abdominal / metabolism Aorta, Thoracic / metabolism Biological Factors / physiology* Blood Glucose / analysis Body Weight / physiology Diabetes Mellitus, Type 2 / physiopathology, therapy* Disease Models, Animal Eating / physiology Endothelium, Vascular / drug effects, physiology Exercise Therapy* Histamine / pharmacology Lipids / blood Male Muscle Relaxation / drug effects Nitric Oxide / physiology*, urine RNA, Messenger / biosynthesis Rats Rats, Inbred OLETF Transforming Growth Factor beta / biosynthesis Transforming Growth Factor beta1 Treatment Outcome Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Factors; 0/Blood Glucose; 0/Lipids; 0/RNA, Messenger; 0/Tgfb1 protein, rat; 0/Transforming Growth Factor beta; 0/Transforming Growth Factor beta1; 0/Vasodilator Agents; 0/endothelium-dependent hyperpolarization factor; 10102-43-9/Nitric Oxide; 51-45-6/Histamine; 51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Increased proliferation of endothelial cells with overexpression of soluble TNF-alpha receptor I gen...
Next Document: Nitric oxide prevents oxidised LDL-induced p53 accumulation, cytochrome c translocation, and apoptos...