Document Detail

Exercise training enhances the skeletal muscle response to radiation-induced oxidative stress.
MedLine Citation:
PMID:  21171096     Owner:  NLM     Status:  In-Process    
Overproduction of reactive oxygen species (ROS) can damage cellular macromolecules and lead to cellular dysfunction or death. Exercise training induces beneficial adaptations in skeletal muscle that may reduce cellular damage from exposure to ROS. To determine the response of exercise-conditioned muscle to acute increases in ROS, four groups of mice were used: non-trained (NT, n = 12); NT + high-dose radiation (HDR, n = 3); exercise-trained (EX, n = 13, 3 days/week for 10 weeks, 10 m/min to 18 m/min); and EX + HDR (n = 3/group). Quadriceps muscle was harvested 3-5 days following the last exercise bout in the training program for measurement of antioxidant enzyme and metabolic enzyme activity. Total superoxide dismutase (41%), and manganese sodium oxide dismutase (51%) activities were significantly increased in radiation-challenged EX mice as compared with unchallenged EX mice (all P ≤ 0.05). No such increase was observed in NT mice. Citrate synthase (42%) and cytochrome c oxidase (38%) activities were both elevated in radiation-challenged EX mice as compared with unchallenged EX mice (both P < 0.05), and no such increase was observed in NT. We demonstrate that preconditioning skeletal muscle with EX enhances the response of antioxidant and mitochondrial enzymes to radiation.
Michael De Lisio; Jan J Kaczor; Nghi Phan; Mark A Tarnopolsky; Douglas R Boreham; Gianni Parise
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Muscle & nerve     Volume:  43     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-64     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley Periodicals, Inc.
Department of Kinesiology, McMaster University, Ivor Wynn Centre, Room 215, Hamilton, Ontario L8S 4L8, Canada.
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Grant Support
//Canadian Institutes of Health Research

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