Document Detail

Exercise training enhanced the expression of myocardial proteins related to cell protection in spontaneously hypertensive rats.
MedLine Citation:
PMID:  15290300     Owner:  NLM     Status:  MEDLINE    
Exercise training could potentially exert beneficial effects on the signaling events associated with cardiac cell apoptosis. Spontaneously hypertensive rats (SHR) were trained 5 days/week on a treadmill (18 m/min for 120 min/day) between the ages of 4 weeks and 1 week, corresponding to the hypertensive accelerating phase. The effect of exercise training on the expression of anti-apoptotic proteins HSP-72, Bcl-2 and protein kinase B (PKB), and the apoptotic proteins Bax and glycogen synthase kinase-3 (GSK-3) was examined. Exercise had a significant acute lowering effect on blood pressure, but this decrease did not attenuate the progressive increase in blood pressure. In the left ventricles of exercised SHR, PKB phosphorylation of both Ser473 and Thr308 residues was significantly increased by 166% and 120%, respectively, compared to sedentary SHR. PKB phosphorylation significantly correlated with GSK-3beta phosphorylation. HSP-72 and Bcl-2 protein expression were increased in the left ventricle of exercised SHR, and associated with the concomitant increased expression of the protein Bax. Thus, the Bcl-2/Bax ratio was not changed by exercise training, suggesting that the anti-apoptotic mechanism was effective in compensating the increase in the expression of the pro-apoptotic protein Bax in the myocardium of the SHR.
Claude Lajoie; Angelino Calderone; Louise Béliveau
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  449     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2005-04-13     Completed Date:  2005-09-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  26-32     Citation Subset:  IM    
Department of Kinesiology, University of Montreal, Succ. Centre-ville, C.P. 6128, Montreal H3C 3J7, Canada.
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MeSH Terms
Blood Pressure / physiology
Cardiotonic Agents / metabolism*
Glycogen Synthase Kinase 3 / metabolism
HSP72 Heat-Shock Proteins
Heart Ventricles / metabolism
Heat-Shock Proteins / metabolism
Myocardium / metabolism*
Physical Conditioning, Animal*
Protein-Serine-Threonine Kinases / metabolism
Proto-Oncogene Proteins / metabolism
Proto-Oncogene Proteins c-akt
Proto-Oncogene Proteins c-bcl-2 / metabolism*
Rats, Inbred SHR
bcl-2-Associated X Protein
Reg. No./Substance:
0/Bax protein, rat; 0/Cardiotonic Agents; 0/HSP72 Heat-Shock Proteins; 0/Heat-Shock Proteins; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-2-Associated X Protein; EC Kinases; EC Proteins c-akt; EC Synthase Kinase 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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