| Exercise training and endothelial progenitor cells in haemodialysis patients. | |
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MedLine Citation:
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PMID: 19383248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Haemodialysis patients have few endothelial progenitor cells (EPCs) and an unfavourable cardiovascular outcome. The effects on peripheral blood CD34(+) cells and EPCs of a 6-month walking exercise programme were studied. Thirty dialysis patients (20 males, age 67 +/- 12 years) were prescribed exercise (two daily 10-min home walking sessions at moderate intensity, group E, n = 16) or not prescribed exercise (control, group C, n = 14). On entry and after 6 months peripheral blood CD34(+) cells, EPCs (assessed as CD34(+) cells co-expressing AC133 and vascular endothelial growth factor receptor 2 [VEGFR2], and as endothelial colony-forming units [e-CFU]) and exercise capacity (6-min walking distance, 6MWD) were evaluated. In group E, 6MWD and e-CFU increased significantly during the study period, with no significant changes in CD34(+) or CD34(+) AC133(+) VEGFR2(+) cell numbers. The change in e-CFU was directly and significantly correlated to patient-reported training load. Group C showed no significant change in any variable. In haemodialysis patients, moderate-intensity exercise selectively increased the number of e-CFU. |
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Authors:
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F Manfredini; G M Rigolin; A M Malagoni; L Catizone; S Mandini; O Sofritti; E Mauro; S Soffritti; B Boari; A Cuneo; P Zamboni; R Manfredini |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of international medical research Volume: 37 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2009 Mar-Apr |
Date Detail:
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Created Date: 2009-04-22 Completed Date: 2009-06-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
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Languages: eng Pagination: 534-40 Citation Subset: IM |
Affiliation:
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Vascular Diseases Center, University of Ferrara, Italy. mdf@unife.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Colony-Forming Units Assay Endothelial Cells / cytology* Exercise / physiology* Female Humans Male Renal Dialysis* Stem Cells / cytology* Walking / physiology |
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