Document Detail

Exercise training and endothelial progenitor cells in haemodialysis patients.
MedLine Citation:
PMID:  19383248     Owner:  NLM     Status:  MEDLINE    
Haemodialysis patients have few endothelial progenitor cells (EPCs) and an unfavourable cardiovascular outcome. The effects on peripheral blood CD34(+) cells and EPCs of a 6-month walking exercise programme were studied. Thirty dialysis patients (20 males, age 67 +/- 12 years) were prescribed exercise (two daily 10-min home walking sessions at moderate intensity, group E, n = 16) or not prescribed exercise (control, group C, n = 14). On entry and after 6 months peripheral blood CD34(+) cells, EPCs (assessed as CD34(+) cells co-expressing AC133 and vascular endothelial growth factor receptor 2 [VEGFR2], and as endothelial colony-forming units [e-CFU]) and exercise capacity (6-min walking distance, 6MWD) were evaluated. In group E, 6MWD and e-CFU increased significantly during the study period, with no significant changes in CD34(+) or CD34(+) AC133(+) VEGFR2(+) cell numbers. The change in e-CFU was directly and significantly correlated to patient-reported training load. Group C showed no significant change in any variable. In haemodialysis patients, moderate-intensity exercise selectively increased the number of e-CFU.
F Manfredini; G M Rigolin; A M Malagoni; L Catizone; S Mandini; O Sofritti; E Mauro; S Soffritti; B Boari; A Cuneo; P Zamboni; R Manfredini
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of international medical research     Volume:  37     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2009 Mar-Apr
Date Detail:
Created Date:  2009-04-22     Completed Date:  2009-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  534-40     Citation Subset:  IM    
Vascular Diseases Center, University of Ferrara, Italy.
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MeSH Terms
Colony-Forming Units Assay
Endothelial Cells / cytology*
Exercise / physiology*
Renal Dialysis*
Stem Cells / cytology*
Walking / physiology

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