Document Detail

Exercise training down-regulates ob gene expression in the genetically obese SHHF/Mcc-fa(cp) rat.
MedLine Citation:
PMID:  9228205     Owner:  NLM     Status:  MEDLINE    
The recently cloned obesity gene (ob) encodes a protein, leptin, which is secreted from adipose tissue and interacts with hypothalamic receptors to decrease appetite, increase energy expenditure, and reduce body lipid stores. The levels of ob mRNA are increased in several models of obesity, consistent with the hypothesis that obese animals may be resistant to the actions of leptin. The present study examined the impact of increased energy expenditure through exercise training on ob mRNA gene expression and body composition in the SHHF/Mc-fa(cp) male rat, a rodent model of obesity, insulin resistance, and type II diabetes. Six week old lean and obese animals were trained 8-12 weeks by treadmill running at 70% peak oxygen uptake, 5 days/wk, for 1.5 hr/day. After endurance training, exercised rats had significantly lower total body fat compared to sedentary rats of the same age, despite maintaining the same body weight. In the obese SHHF/Mcc-fa(cp) rat, the level of ob mRNA expression was markedly increased by four fold in subcutaneous adipose tissue compared to lean controls (p<0.05). In response to exercise training, there was a significant 85 % decrease in ob mRNA in exercised-training lean rats (p < 0.05) compared with non-exercised controls, while in obese-exercised rats, ob gene expression was significantly reduced only by 50% relative to non-exercised obese rats (p < 0.05). These results demonstrate that exercise training reduces fat mass and ob mRNA in lean and obese rats, and supports the hypothesis of a feedback loop between the adipocyte and hypothalamus that attempts to maintain body weight at a constant level by reducing ob gene expression in response to increased energy expenditure.
J E Friedman; C M Ferrara; K S Aulak; M Hatzoglou; S A McCune; S Park; W M Sherman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  29     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-09-05     Completed Date:  1997-09-05     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  214-9     Citation Subset:  IM    
Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH 44106-4935, USA.
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MeSH Terms
Adipose Tissue / metabolism
Down-Regulation / physiology*
Gene Expression / genetics
Obesity / genetics*
Physical Conditioning, Animal / physiology*
RNA, Messenger / metabolism
Grant Support
Reg. No./Substance:
0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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