Document Detail

Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue.
MedLine Citation:
PMID:  19121629     Owner:  NLM     Status:  MEDLINE    
Increased oxidative stress in adipocytes causes dysregulated expression of inflammation-related adipokines. We have examined the effects of exercise training on oxidative stress in rat white adipose tissue (WAT), especially focusing on inflammation-related adipokines. The levels of lipid peroxidation in WAT of exercise-trained (TR) rats were lower than those in control (C) rats. The content of manganese-containing superoxide dismutase in WAT of TR rats was increased as compared with those in C rats. In contrast, the expression of the NADPH oxidase NOX2 protein in WAT was downregulated by exercise training. Moreover, the levels of inflammation-related adipokines, such as tumor necrosis factor-alpha and monocyte chemoattractant protein-1, in WAT of TR rats were lower than those in C rats. The effects of exercise training were more remarkable in visceral WAT than in subcutaneous. These results suggest that exercise training decreases the expression of inflammation-related adipokines by reducing oxidative stress in WAT.
Takuya Sakurai; Tetsuya Izawa; Takako Kizaki; Jun-etsu Ogasawara; Ken Shirato; Kazuhiko Imaizumi; Kazuto Takahashi; Hitoshi Ishida; Hideki Ohno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-01
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  379     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-02-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  605-9     Citation Subset:  IM    
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan.
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MeSH Terms
Adipokines / biosynthesis*
Adipose Tissue, White / metabolism*
Extracellular Signal-Regulated MAP Kinases / metabolism
Inflammation / metabolism*
Lipid Peroxidation
Membrane Glycoproteins / biosynthesis
NADPH Oxidase / biosynthesis
Oxidative Stress / physiology*
Physical Conditioning, Animal*
Rats, Wistar
Superoxide Dismutase / metabolism
Reg. No./Substance:
0/Adipokines; 0/Membrane Glycoproteins; EC Dismutase; EC 1.6.-/Cybb protein, rat; EC Oxidase; EC Signal-Regulated MAP Kinases

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