Document Detail

Exercise training confers anticipatory protection from sudden death during acute myocardial ischemia.
MedLine Citation:
PMID:  8313542     Owner:  NLM     Status:  MEDLINE    
Seven conscious dogs documented to be at high risk by the occurrence of ventricular fibrillation (VF) during acute myocardial ischemia were randomly assigned to 6 weeks of either daily exercise training or cage rest followed by exercise training. After 6 weeks of daily treadmill training, heart rate variability, a marker of vagal tone, increased by 74% (P < .001); baroreflex sensitivity, a marker of the capability to reflexly augment vagal activity, increased by 69% (P < .01); the repetitive extrasystole threshold, a marker of ventricular electrical stability, increased by 44% (P < .05). After exercise training, the incidence of ventricular fibrillation during acute myocardial ischemia decreased by 100%, as all animals survived. Neither passage of time nor heart rate level during ischemia contributed to the outcome. The most likely mechanism to explain the striking change in risk status is the shift in autonomic balance characterized by increased cardiac vagal activity, which was previously shown to have an antifibrillatory effect. These results suggest that exercise training in healthy individuals may decrease their likelihood of developing lethal arrhythmias during acute myocardial ischemia.
S S Hull; E Vanoli; P B Adamson; R L Verrier; R D Foreman; P J Schwartz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  89     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-03-18     Completed Date:  1994-03-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  548-52     Citation Subset:  AIM; IM    
Department of Physiology, College of Medicine, University of Oklahoma Health Science Center, Oklahoma City 73190.
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MeSH Terms
Acute Disease
Death, Sudden / etiology*
Heart Rate
Myocardial Ischemia / complications*,  mortality,  physiopathology
Physical Conditioning, Animal*
Survival Analysis
Ventricular Fibrillation / etiology,  prevention & control
Grant Support
Comment In:
Circulation. 1994 Sep;90(3):1578-9   [PMID:  8087969 ]
Circulation. 1994 Nov;90(5):2564   [PMID:  7955220 ]

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