| Exercise training can attenuate preeclampsia-like features in an animal model. | |
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MedLine Citation:
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PMID: 20811291 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: Exercise training benefits have been widely investigated and used as alternative treatment for different pathological conditions. Since preeclampsia is a severe pregnancy-associated disease for which no treatment is available, our aim was to investigate the protective role of exercise training on pregnancy outcome using a mouse model of the disease. METHODS: We used transgenic female mice overexpressing human angiotensinogen, which develop preeclampsia when mated with human renin-overexpressing males. Females were placed in exercise cages 4 weeks prior to mating, and remained in these throughout gestation. Blood pressure was measured by telemetry, and proteinuria was quantified by ELISA. Placentas were assessed by histology and immunohistochemistry, whereas vascular endothelial growth factor was measured by real-time PCR and immunoblot. Endothelial function was assessed in isolated mesenteric arteries. RESULTS: Conversely to sedentary transgenic females (131.20 ± 4.08 mmHg), trained dam's mean arterial pressure was no longer different from normal mice at the end of gestation (117.5 ± 10.6 vs. 112.3 ± 5.5 mmHg). Proteinuria observed in transgenic dams (3.364 ± 1.62 μg/mg) was absent in trained mice (0.894 ± 0.43 μg/mg). Placental disease and cardiac hypertrophy were also normalized, whereas vascular reactivity was significantly ameliorated. Furthermore, placental vascular endothelial growth factor was normalized in trained transgenic mice. CONCLUSIONS: To our knowledge, we are the first to clearly demonstrate that exercise training both before and during gestation can reduce preeclampsia features in a mouse model. Consequently, women at risk for this disease could benefit from exercise training to protect themselves and their future fetuses. |
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Authors:
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Stéphanie Falcao; Sandra Bisotto; Catherine Michel; Andrée-Anne Lacasse; Cathy Vaillancourt; Jolanta Gutkowska; Julie L Lavoie |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-01-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 2446-53 Citation Subset: IM |
Affiliation:
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aResearch Centre, Centre hospitalier de l'Université de Montréal (CRCHUM) - Technopôle Angus, Montreal, Canada bDepartment of Biomedical Sciences, Université de Montréal, Montreal, Canada cINRS-Institut Armand-Frappier, Université du Québec, Laval, Canada dCRCHUM - Hôtel-Dieu, Canada eDepartment of Medicine, Université de Montréal, Montreal, Quebec, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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