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MedLine Citation:
PMID:  25038103     Owner:  NLM     Status:  Publisher    
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation. This study sought to assess the effects of an exercise training program on cytokines and soluble TNF receptors in response to acute exercise in SLE women. Eight SLE women and ten sex-, age- and BMI-comparable healthy controls (HC) participated in this study. Prior to and after a 12-week aerobic exercise training program, cytokines and soluble TNF receptors were assessed at rest and in response to single bouts of acute moderate/intense exercise. HC performed the acute exercise bouts only at baseline. After the exercise training program, there was a decrease in resting sTNFR2 levels (P=0.025) and a tend to reduction IL-10 levels (P=0.093) in SLE. The resting levels of IL-6, IL-10, and TNF-α after the exercise training in SLE reached HC levels (P>0.05). In response to a single bout of acute moderate exercise, the area under the curve (AUC) of IL-10 was significantly reduced after the exercise training program in SLE (P=0.043), and the AUC of IL-10, IL-6, TNF-α, and sTNFR1 of SLE approached control values (P>0.05). In response to a single bout of acute intense exercise, the AUC of IL-10 was significantly reduced in SLE (P=0.015). Furthermore, the AUC of sTNFR2 tended to decrease after exercise training program in SLE (P=0.084), but it did not reach control values (P=0.001). An aerobic exercise training program attenuated the inflammatory milieu in SLE women, revealing a novel homeostatic immunomodulatory role of exercise in an autoimmunity condition.
Luiz Augusto Perandini; Diego Sales-de-Oliveira; Suzana Beatriz Veríssimo Mello; Niels Olsen Camara; Fabiana Braga Benatti; Fernanda Rodrigues Lima; Eduardo Borba; Eloisa Bonfa; Ana Lúcia Sá-Pinto; Hamilton Roschel; Bruno Gualano
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-18
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  -     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014, Journal of Applied Physiology.
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