Document Detail

Exercise training attenuates progressive decline in brachial artery reactivity in heart transplant recipients.
MedLine Citation:
PMID:  18187087     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Heart transplantation normalizes central hemodynamics, but endothelial dysfunction persists after transplantation. METHODS: To investigate the effects of aerobic exercise on arterial function, oxidative stress, lipid profile, and sympathetic nervous system activity, 20 heart transplant recipients (age, 54.3 +/- 9.1 years; 17 men, 3 women) were randomly assigned to 12 weeks of supervised treadmill exercise (Trained; n = 10) or standard medical care (Control; n = 10). Supervised exercise was initiated at 8 weeks after transplant. Brachial artery reactivity was assessed using flow-mediated dilation. RESULTS: The VO2 peak increased 26% in the Trained patients (15.4 +/- 4.3 vs 19.4 +/- 5.5 ml/kg/min; p < or = 0.05) but did not change in the Controls (16.2 +/- 5.2 vs 16.8 +/- 2.8 ml/kg/min; p > or = 0.05). Brachial artery flow-mediated dilation (10.1% +/- 6.1% vs 9.6% +/- 6.2%) and absolute brachial diameter (0.48 +/- 0.22 vs 0.42 +/- 0.24 mm) did not change in Trained patients, but brachial flow-mediated dilation (10.5% +/- 2.8% vs 7.9% +/- 5.1%) and the absolute change in brachial diameter (0.48 +/- 0.16 vs 0.36 +/- 0.24 mm) decreased significantly (p < or = 0.05) in the Control patients. Resting norepinephrine decreased significantly (p < or = 0.05) after training (0.32 +/- 0.19 vs 0.22 +/- 0.22 ng/ml), but there was a nonsignificant trend toward increased norepinephrine in the Controls (0.26 +/- 0.17 vs 0.53 +/- 0.41 ng/ml; p = 0.07). The lipid profile and marker of oxidative stress did not differ between the groups before or after the intervention. CONCLUSIONS: To our knowledge, this is the first prospective, randomized study to investigate the effects of heart transplantation and aerobic exercise on peripheral artery function in the same cohort of heart transplant recipients. Brachial artery flow-mediated dilation increased early in the post-operative period. Aerobic exercise preserved but did not improve brachial artery flow-mediated dilation. Heart transplant recipients who did not participate in supervised exercise showed a progressive decline in brachial artery flow-mediated dilation.
Randy W Braith; Richard S Schofield; James A Hill; Darren P Casey; Gary L Pierce
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  27     ISSN:  1557-3117     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-11     Completed Date:  2008-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  52-9     Citation Subset:  IM    
Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida 32611, USA.
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MeSH Terms
Brachial Artery / physiology*
Exercise / physiology*
Exercise Therapy / methods*
Follow-Up Studies
Heart Failure / surgery
Heart Transplantation / physiology*
Middle Aged
Oxygen Consumption / physiology
Vasodilation / physiology*
Ventricular Function, Left / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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