Document Detail


Exercise training attenuates lipectomy-induced impaired glucose tolerance in rats.
MedLine Citation:
PMID:  19817505     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Since visceral adipose tissue (VAT) may account for impaired peripheral and hepatic insulin sensitivity (IS), it has been hypothesized that the partial removal of VAT could result in improved insulin action, while the re-growth of the excised tissue and/or compensatory growth of non-excised depots seems to occur. Thus, it was aimed to investigate whether or not VAT removal and exercise affect IS. METHODS: Male Wistar rats were fed a high-fat diet and subsequently assigned randomly to one of four groups: 1. exercised plus lipectomized (EL), 2. exercised plus sham-lipectomized (ES), 3. sedentary plus lipectomized (CL), 4. sedentary plus sham-lipectomized (CS). After lipectomy, EL and ES animals underwent a 7-consecutive-day training period. Body weight, food intake, basal metabolic rate, fasting glucose, and glucose tolerance were assessed before and after the interventions. Fasting insulin and the HOMA index, body fat mass, and the expression of pro-inflammatory genes were assessed after the interventions. RESULTS: EL group showed greater insulin sensitivity compared to all other groups. EL and ES groups showed lower fasting insulin levels when compared to CL and CS groups, respectively. The EL group showed improved IS when compared to the remaining groups. The CL group showed impaired glucose tolerance and increased TNF-alpha gene expression. Body weight and fat mass did not differ among the groups. PPAR gamma gene expression was increased in the EL and ES groups. CONCLUSIONS: These results showed that short-term swimming training improved insulin sensitivity, but failed to prevent fat regain in lipectomized animals. Lipectomy induced impaired glucose tolerance, which is probably related to increased TNF-alpha gene expression. It is possible that a high-fat diet might be implicated in faster regain of adipose tissue after lipectomy. Our results also show that short-term exercise associated with lipectomy could improve insulin sensitivity.
Authors:
D F Coelho; B Gualano; G G Artioli; H Roschel; M Amano; F B Benatti; T Fernandes; C R Bueno; N O Câmara; A H Lancha
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrine regulations     Volume:  43     ISSN:  1210-0668     ISO Abbreviation:  Endocr Regul     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-10-12     Completed Date:  2009-11-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112018     Medline TA:  Endocr Regul     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  107-16     Citation Subset:  IM    
Affiliation:
Escola de Educação Física e Esporte, Universidade de São Paulo, SP, Brasil. decoelho@usp.br
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MeSH Terms
Descriptor/Qualifier:
Abdominal Fat / metabolism
Adipose Tissue / chemistry
Adiposity
Animals
Basal Metabolism
Biological Markers / metabolism
Blood Glucose / analysis
Body Weight
Diet
Dietary Fats / administration & dosage*
Energy Intake
Epididymis
Fasting / blood
Glucose Intolerance / etiology,  prevention & control*
Glucose Tolerance Test
Inflammation / metabolism
Insulin / blood
Lipectomy / adverse effects*
Male
Muscle, Skeletal / metabolism
PPAR alpha / genetics,  metabolism
Physical Conditioning, Animal / physiology*
RNA, Messenger / metabolism
Random Allocation
Rats
Rats, Wistar
Swimming
Tumor Necrosis Factor-alpha / genetics,  metabolism
Weight Gain / physiology*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Dietary Fats; 0/PPAR alpha; 0/RNA, Messenger; 0/Tumor Necrosis Factor-alpha; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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