Document Detail

Exercise training accelerates the removal from plasma of LDL-like nanoemulsion in moderately hypercholesterolemic subjects.
MedLine Citation:
PMID:  20627247     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Exercise training improves plasma lipid profile and diminishes risk of coronary heart disease. Previously, we showed that training increases LDL plasma clearance, as tested by an artificial LDL-like nanoemulsion method, presumably by increasing LDL receptor activity. In this study, we investigated whether training could also improve LDL clearance in hypercholesterolemic subjects (HCh) that are exposed to increased risk of cardiovascular events.
METHODS: Twenty sedentary HCh and 20 normolipidemic (NL) sedentary volunteers were divided into four groups: 12 HCh submitted to 4-month training program, 8 HCh with no exercise program, 12 NL submitted to 4-month training and 8 NL with no exercise program. An LDL-like nanoemulsion labeled with (14)C-cholesteryl ester was injected intravenously into all subjects and plasma samples were collected during 24 h after injection to determine the fractional clearance rate (FCR, in h(-1)) by compartmental analysis. The study was performed on the first and on the last day of the 4-month study period.
RESULTS: In both, trained HCh and NL groups, training increased nanoemulsion FCR by 36% (0.0443+/-0.0126; 0.0602+/-0.0187, p=0.0187 and 0.0503+/-0.0203; 0.0686+/-0.0216, p=0.0827, respectively). After training, LDL cholesterol diminished in both HCh and NL groups. In HCh, but not in NL group, LDL susceptibility to oxidation decreased, but oxidized LDL was unchanged. In both non-trained groups FCR was the same for the last and the 4-month previous evaluation.
CONCLUSION: In HCh, exercise training increased the removal of LDL as tested by the nanoemulsion, and this probably accounted for decreased LDL cholesterol and diminished LDL susceptibility to oxidation.
Elisabeth S Ficker; Raul C Maranhão; Ana P M Chacra; Vanessa C Neves; Carlos E Negrão; Vanessa C N Martins; Carmen G C de M Vinagre
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-06
Journal Detail:
Title:  Atherosclerosis     Volume:  212     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-03     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  230-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Heart Institute (InCor) of the Medical School Hospital, University of São Paulo, São Paulo, Brazil.
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MeSH Terms
Biological Markers / blood
Cholesterol Esters / administration & dosage,  blood*,  pharmacokinetics
Cholesterol, LDL / administration & dosage,  blood*,  pharmacokinetics
Exercise Therapy*
Hypercholesterolemia / blood,  therapy*
Injections, Intravenous
Lipoproteins, LDL / blood
Middle Aged
Time Factors
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol Esters; 0/Cholesterol, LDL; 0/Emulsions; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein

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