| Exercise tolerance, exercise hyperpnea and central chemosensitivity to carbon dioxide in sleep apnea syndrome in heart failure patients. | |
| | |
MedLine Citation:
|
PMID: 15914948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Sleep apnea syndrome (SAS) and exercise hyperpnea are common in patients with chronic heart failure (CHF), and although it is not known whether they are both regulated by the same mechanisms, the hypothesis of the present study was that they are related to augmented central chemosensitivity. METHODS AND RESULTS: The oxygen desaturation index (ODI) was evaluated in 29 patients and those with ODI > 5 times/h underwent polysomnography. Patients with an apnea-hypopnea index (AHI) > 15 /h without evidence of obstructive apnea were defined as central SAS (CSAS). Cardiopulmonary exercise testing was performed to determine peak oxygen uptake and the VE-VCO2 slope. A hypercapnic gas mixture (7% CO2/93% O2) was used to activate the central chemoreflex. Nine patients had central SAS (CHF-CSAS) and 20 did not have apnea (CHF-nonSAS). Patients with CHF-CSAS had a lower peak oxygen uptake than the CHF-nonSAS group (13.0+/-2.4 vs 16.9+/-4.3 ml x kg(-1) x min(-1), p < 0.05). There was a significant correlation between central chemosensitivity and the AHI (r = 0.63, p < 0.05), between central chemosensitivity and the VE - VCO2 slope (r = 0.50, p < 0.01), whereas the VE-VCO2 slope showed an insignificant tendency to correlate with AHI (r = 0.44, p = 0.07). Conclusion CHF-CSAS is associated with impaired exercise tolerance and elevated central chemosensitivity is the responsible mechanism for CSAS and exercise hyperpnea. |
| | |
Authors:
|
Kentaro Meguro; Hitoshi Adachi; Shigeru Oshima; Koichi Taniguchi; Ryozo Nagai |
Related Documents
:
|
18514618 - Oral amino acid supplements improve exercise capacities in elderly patients with chroni... 16158008 - Exercise duration and peak systolic blood pressure are predictive of mortality in ambul... 11150968 - Normal skeletal muscle na(+)-k(+) pump concentration in patients with chronic heart fai... 8007798 - Exercise testing and training in patients with chronic heart failure. 16175498 - Exercise as a stress model and the interplay between the hypothalamus-pituitary-adrenal... 11098298 - Effect of cpap on breathlessness perception in healthy subjects during methacholine ind... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 69 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2005 Jun |
Date Detail:
|
Created Date: 2005-05-25 Completed Date: 2005-09-01 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
|
Languages: eng Pagination: 695-9 Citation Subset: IM |
Affiliation:
|
Department of Cardiovascular Medicine, Tokyo University Graduate School of Medicine, Tokyo, Japan. meguro@med.email.ne.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Carbon Dioxide* / analysis Exercise* Exercise Tolerance* Female Heart Failure / complications, physiopathology* Humans Male Middle Aged Sleep Apnea Syndromes / complications, physiopathology* |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Novel Doppler technique to assess systemic vascular resistance: the snuffbox technique.
Next Document: Comparison of the rheologic parameters in left internal thoracic artery grafts with those in sapheno...