Document Detail

Exercise tolerance and blood pressure response to exercise testing in children and adolescents after renal transplantation.
MedLine Citation:
PMID:  9770574     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to assess exercise tolerance and blood pressure (BP) response to treadmill exercise in children after renal transplantation. Forty-five children were selected (29 males and 16 females) whose mean age was 14.3 +/- 4.2 years. All children had Hb >/= 10 g/dl and creatinine clearance >/=40 ml/min/1.73 m2. They were at least 6 months posttransplantation and were on triple immunosuppressive therapy. Twenty-seven were also on various antihypertensive medications. Each underwent clinical examination and measurement of BP, both at rest and during exercise testing on treadmill. The test was stopped on muscular fatigue or exhaustion. The patients were divided into two groups: those off (A) or on (B) antihypertensive therapy. When compared to a population of healthy children the patients had reduced exercise tolerance (10.1 +/- 2.1 vs 15.1 +/- 1.7 min, p < 0.001) (67 +/- 16%), increased heart rate (174 +/- 19 vs 161 +/- 19 beats/min, p < 0.001) (109 +/- 15%), and increased maximum systolic BP (150 +/- 26 vs 134 +/- 13 mmHg, p < 0. 001) (113 +/- 19%) at comparable workloads. Within the two patient groups, significant differences were observed during exercise testing for maximum heart rate, which was lower in group B (p = 0.03), and maximum systolic BP, which was higher in group A (p = 0.04). Our study confirms that children and adolescents on immunosuppressive therapy after renal transplantation have a hypertensive response during exercise, probably related to medication-induced peripheral vascular tone.
U Giordano; A Calzolari; M C Matteucci; E Pastore; A Turchetta; G Rizzoni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric cardiology     Volume:  19     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    1998 Nov-Dec
Date Detail:
Created Date:  1999-01-04     Completed Date:  1999-01-04     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  471-3     Citation Subset:  IM    
Sports Medicine Department, Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio, 4-00165 Roma, Italy.
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MeSH Terms
Blood Pressure / physiology*
Exercise Test*
Heart Rate / physiology
Kidney Transplantation / physiology*
Postoperative Complications / physiopathology*
Reference Values
Vascular Resistance / physiology

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