Document Detail

Exercise to reduce the escalation of cocaine self-administration in adolescent and adult rats.
MedLine Citation:
PMID:  22752381     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Concurrent access to an exercise wheel decreases cocaine self-administration under short access (5 h/day for 5 days) conditions and suppresses cocaine-primed reinstatement in adult rats.
OBJECTIVE: The effect of exercise (wheel running) on the escalation of cocaine intake during long access (LgA, 6 h/day for 26 days) conditions was evaluated.
METHODS: Adolescent and adult female rats acquired wheel running, and behavior was allowed to stabilize for 3 days. They were then implanted with an iv catheter and allowed to self-administer cocaine (0.4 mg/kg, iv) during 6-h daily sessions for 16 days with concurrent access to either an unlocked or a locked running wheel. Subsequently, for ten additional sessions, wheel access conditions during cocaine self-administration sessions were reversed (i.e., locked wheels became unlocked and vice versa).
RESULTS: In the adolescents, concurrent access to the unlocked exercise wheel decreased responding for cocaine and attenuated escalation of cocaine intake irrespective of whether the locked or unlocked condition came first. However, cocaine intake increased when the wheel was subsequently locked for the adolescents that had initial access to an unlocked wheel. Concurrent wheel access either before or after the locked wheel access did not reduce cocaine intake in adults.
CONCLUSIONS: Wheel running reduced cocaine intake during LgA conditions in adolescent but not adult rats, and concurrent access to the running wheel was necessary. These results suggest that exercise prevents cocaine seeking and that this effect is more pronounced in adolescents than adults.
Natalie E Zlebnik; Justin J Anker; Marilyn E Carroll
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-03
Journal Detail:
Title:  Psychopharmacology     Volume:  224     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-04-29     Revised Date:  2013-09-18    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  387-400     Citation Subset:  IM    
Department of Psychiatry, University of Minnesota, MMC 392, Minneapolis, MN 55455, USA.
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MeSH Terms
Age Factors
Behavior, Addictive / psychology*
Behavior, Animal / drug effects*
Central Nervous System Stimulants / administration & dosage*
Cocaine / administration & dosage*
Cocaine-Related Disorders / prevention & control*,  psychology
Conditioning, Operant
Drug-Seeking Behavior / drug effects*
Infusions, Intravenous
Physical Exertion*
Rats, Wistar
Reinforcement (Psychology)
Self Administration
Time Factors
Grant Support
K05 DA015267-10/DA/NIDA NIH HHS; R01 DA003240-28/DA/NIDA NIH HHS; T32 GM008471/GM/NIGMS NIH HHS
Reg. No./Substance:
0/Central Nervous System Stimulants; 50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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