Document Detail

Exercise to exhaustion in the second-wind phase of exercise in a case of McArdle's disease with and without creatine supplementation.
MedLine Citation:
PMID:  12774595     Owner:  NLM     Status:  MEDLINE    
The cardio-pulmonary and biochemical changes observed in a case of McArdle's disease, exercising with increasing work rates to exhaustion in the "second-wind" phase of exercise are reported for the first time. A work rate of 275-325 watts was achieved. Venous blood lactate remained unchanged throughout. The plasma ammonium level reached a plateau of approximately 400 mmol/l at 100 watts. At a work rate of 150-175 watts the ratio of O2 consumption to CO2 production increased, the inverse of an anaerobic threshold. Maximal cardiopulmonary responses were achieved at 200 watts. During the final periods of exercise from 200 to 275/325 watts pulmonary ventilation did not significantly change but there was a decrease in the venous blood H+ concentration, and pO2 and in increase in the pCO2. Creatine supplementation at 25 g/day for five days did not improve exercise performance.
D St J O'Reilly; R Carter; E Bell; J Hinnie; P J Galloway
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Scottish medical journal     Volume:  48     ISSN:  0036-9330     ISO Abbreviation:  Scott Med J     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-30     Completed Date:  2003-09-08     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  2983335R     Medline TA:  Scott Med J     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  46-8     Citation Subset:  IM    
Department of Clinical Biochemistry, Glasgow Royal Infirmary, Glasgow G4 0SF.
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MeSH Terms
Creatinine / pharmacology*
Dietary Supplements*
Exercise Tolerance / drug effects*
Glycogen Storage Disease Type V / physiopathology*
Middle Aged
Quaternary Ammonium Compounds / blood
Reg. No./Substance:
0/Quaternary Ammonium Compounds; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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