| Exercise to exhaustion in the second-wind phase of exercise in a case of McArdle's disease with and without creatine supplementation. | |
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MedLine Citation:
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PMID: 12774595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cardio-pulmonary and biochemical changes observed in a case of McArdle's disease, exercising with increasing work rates to exhaustion in the "second-wind" phase of exercise are reported for the first time. A work rate of 275-325 watts was achieved. Venous blood lactate remained unchanged throughout. The plasma ammonium level reached a plateau of approximately 400 mmol/l at 100 watts. At a work rate of 150-175 watts the ratio of O2 consumption to CO2 production increased, the inverse of an anaerobic threshold. Maximal cardiopulmonary responses were achieved at 200 watts. During the final periods of exercise from 200 to 275/325 watts pulmonary ventilation did not significantly change but there was a decrease in the venous blood H+ concentration, and pO2 and in increase in the pCO2. Creatine supplementation at 25 g/day for five days did not improve exercise performance. |
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Authors:
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D St J O'Reilly; R Carter; E Bell; J Hinnie; P J Galloway |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Scottish medical journal Volume: 48 ISSN: 0036-9330 ISO Abbreviation: Scott Med J Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-30 Completed Date: 2003-09-08 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2983335R Medline TA: Scott Med J Country: Scotland |
Other Details:
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Languages: eng Pagination: 46-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Biochemistry, Glasgow Royal Infirmary, Glasgow G4 0SF. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Creatinine
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pharmacology* Dietary Supplements* Exercise Tolerance / drug effects* Glycogen Storage Disease Type V / physiopathology* Humans Male Middle Aged Quaternary Ammonium Compounds / blood |
| Chemical | |
Reg. No./Substance:
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0/Quaternary Ammonium Compounds; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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