Document Detail


Exercise and time-dependent benefits to learning and memory.
MedLine Citation:
PMID:  20219647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While it is well established that exercise can improve cognitive performance, it is unclear how long these benefits endure after exercise has ended. Accordingly, the effects of voluntary exercise on cognitive function and brain-derived neurotrophic factor (BDNF) protein levels, a major player in the mechanisms governing the dynamics of memory formation and storage, were assessed immediately after a 3-week running period, or after a 1-week or 2-week delay following the exercise period. All exercised mice showed improved performance on the radial arm water maze relative to sedentary animals. Unexpectedly, fastest acquisition (fewest errors and shortest latency) occurred in animals trained following a 1-week delay, while best memory performance in the probe trial was observed in those trained immediately after the exercise period. Assessment of the time course of hippocampal BDNF availability following exercise revealed significant elevations of BDNF immediately after the exercise period (186% of sedentary levels) and at 1 and 2 weeks after exercise ended, with levels returning to baseline by 3-4 weeks. BDNF protein levels showed a positive correlation with cognitive improvement in radial water maze training and with memory performance on day 4, supporting the idea that BDNF availability contributes to the time-dependent cognitive benefits of exercise revealed in this study. Overall, this novel approach assessing the temporal endurance of cognitive and biochemical effects of exercise unveils new concepts in the exercise-learning field, and reveals that beneficial effects of exercise on brain plasticity continue to evolve even after exercise has ended.
Authors:
N C Berchtold; N Castello; C W Cotman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-02-26
Journal Detail:
Title:  Neuroscience     Volume:  167     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-06-29     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  588-97     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
Affiliation:
Institute for Memory Impairment and Neurobiological Disorders, University of California, Irvine, CA 92697-4545, USA. nberchto@uci.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain-Derived Neurotrophic Factor / metabolism*
Cognition Disorders / therapy
Hippocampus / metabolism*
Learning / physiology*
Male
Maze Learning / physiology
Memory / physiology*
Memory Disorders / therapy
Mice
Mice, Inbred C57BL
Neuronal Plasticity / physiology*
Physical Conditioning, Animal / physiology*
Time Factors
Up-Regulation / physiology
Grant Support
ID/Acronym/Agency:
R01 AG034667/AG/NIA NIH HHS; R01 AG034667-01/AG/NIA NIH HHS; R01 AG034667-01/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor
Comments/Corrections

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