Document Detail


Exercise therapy correlates with improving renal function through modifying lipid metabolism in patients with cardiovascular disease and chronic kidney disease.
MedLine Citation:
PMID:  20696551     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Patients with cardiovascular disease (CVD) and chronic kidney disease (CKD) are at high risk of cardiovascular mortality, thus therapies to improve renal function should be clinically investigated.
METHODS AND RESULTS: We divided consecutive patients with CVD and CKD (n=19) into exercise (n=10) and non-exercise (n=9) therapy groups. Exercise therapy for 12 weeks significantly improved the anaerobic metabolic threshold (AT-V O₂) and high-density lipoprotein cholesterol (HDL-C) levels, and reduced triglyceride levels. Exercise therapy also improved estimated glomerular filtration rate (eGFR). Change in eGFR correlated significantly and positively with change in AT-V O₂ and HDL-C, and negatively with change in triglyceride levels.
CONCLUSIONS: Exercise therapy correlates with improving renal function in CVD patients with CKD through modifying lipid metabolism. Exercise therapy could be an effective clinical strategy to improve renal function.
Authors:
Kensuke Toyama; Seigo Sugiyama; Hideki Oka; Hitoshi Sumida; Hisao Ogawa
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2010-08-08
Journal Detail:
Title:  Journal of cardiology     Volume:  56     ISSN:  0914-5087     ISO Abbreviation:  J Cardiol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  142-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Cardiovascular Medicine, Faculty of Life Science, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Cardiovascular Diseases / physiopathology,  therapy*
Cholesterol, HDL / blood
Exercise Therapy*
Female
Glomerular Filtration Rate
Humans
Kidney / physiology*
Kidney Failure, Chronic / physiopathology,  therapy*
Lipid Metabolism / physiology*
Male
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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