| Exercise thallium-201 tomographic scintigraphy in the diagnosis of coronary artery disease: emphasis on the effect of exercise level. | |
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MedLine Citation:
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PMID: 1363212 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise thallium-201 imaging using single-photon emission computed tomography (SPECT) was evaluated in 154 patients with angiographically documented coronary artery disease (CAD) and in 25 normal subjects. Of the 154 patients with CAD, 134 (87%) had abnormal thallium images. By contrast, only 77 (50%) patients had ischemic ST-segment depression (p < 0.001). Among 25 normal subjects, 20 had normal exercise SPECT images. The specificity of exercise SPECT imaging (80% or 20/25) in excluding patients with CAD was not significantly higher than that of exercise electrocardiography (76% or 19/25). For the detection of individual vessel involvement by analysis of territories of perfusion abnormalities, the sensitivity and specificity of exercise SPECT were 72% and 96% for the left anterior descending, 78% and 85% for the right coronary, and 47% and 98% for the left circumflex artery. Ninety (group 1) of the 154 patients with CAD achieved adequate exercise end points (ischemic ST-segment depression or > 85% of maximal predicted heart rate) and 64 (group 2) did not. Exercise SPECT showed significantly more perfusion abnormalities in group 1 than in group 2 (96% vs 75%, p < 0.001). We conclude that: (1) exercise SPECT thallium imaging is more sensitive than exercise electrocardiography for detecting patients with CAD; (2) the sensitivity of the test is affected by the level of exercise; and (3) it is valuable in the identification of individual vessel involvement. |
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Authors:
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P J Huang; P U Chieng; Y T Lee; F T Chiang; Y Z Tseng; C S Liau; C D Tseng; C T Su; W P Lien |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the Formosan Medical Association = Taiwan yi zhi Volume: 91 ISSN: 0929-6646 ISO Abbreviation: J. Formos. Med. Assoc. Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1993-03-24 Completed Date: 1993-03-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9214933 Medline TA: J Formos Med Assoc Country: HONG KONG |
Other Details:
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Languages: eng Pagination: 1096-101 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, R.O.C. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Disease
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diagnosis,
radionuclide imaging* Electrocardiography Exercise Test* Female Humans Male Middle Aged Sensitivity and Specificity Thallium Radioisotopes / diagnostic use* Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Thallium Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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