Document Detail


Exercise testing of the chronic effects of bunazosin hydrochloride on dilated cardiomyopathy.
MedLine Citation:
PMID:  2576205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bunazosin hydrochloride (Detantol) was administrated in 3-mg oral doses to 10 patients (6 males and 4 females, average 49.9 years) with dilated cardiomyopathy (DCM) of class II in the NYHA functional classification. The patients were observed for changes in their hemodynamics at rest, chest X-ray, echocardiography, humoral factors and symptom-limited exercise tolerance with treadmill testing before treatment and 4 and 8 weeks after administration. All but the left ventricular end-diastolic diameter after 8 weeks were unchanged. Of the humoral factors, only aldosterone decreased significantly during the treatment. On the other hand, the duration of symptom-limited exercise was prolonged significantly, and for a given exercise load, a reduction of heart rate and systolic blood pressure as well as a drop in the pressure-rate product occurred at 8 weeks after administration. Therefore, bunazosin appears to improve cardiac function and exercise tolerance in the patients with DCM, at dosages which do not affect hemodynamics at rest.
Authors:
A Nakano; M Tamura; M Hatori; A Hasegawa; T Suzuki; K Murata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  39     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-03-27     Completed Date:  1990-03-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1590-2     Citation Subset:  IM    
Affiliation:
Second Department of Internal Medicine, School of Medicine, Gunma University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenergic alpha-Antagonists / adverse effects,  therapeutic use*
Adult
Aged
Cardiomyopathy, Dilated / drug therapy*,  physiopathology
Echocardiography
Electrocardiography
Exercise Test*
Female
Hemodynamics / drug effects
Humans
Male
Middle Aged
Quinazolines / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Quinazolines; 80755-51-7/bunazosin

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