Document Detail

Exercise testing of the chronic effects of bunazosin hydrochloride on dilated cardiomyopathy.
MedLine Citation:
PMID:  2576205     Owner:  NLM     Status:  MEDLINE    
Bunazosin hydrochloride (Detantol) was administrated in 3-mg oral doses to 10 patients (6 males and 4 females, average 49.9 years) with dilated cardiomyopathy (DCM) of class II in the NYHA functional classification. The patients were observed for changes in their hemodynamics at rest, chest X-ray, echocardiography, humoral factors and symptom-limited exercise tolerance with treadmill testing before treatment and 4 and 8 weeks after administration. All but the left ventricular end-diastolic diameter after 8 weeks were unchanged. Of the humoral factors, only aldosterone decreased significantly during the treatment. On the other hand, the duration of symptom-limited exercise was prolonged significantly, and for a given exercise load, a reduction of heart rate and systolic blood pressure as well as a drop in the pressure-rate product occurred at 8 weeks after administration. Therefore, bunazosin appears to improve cardiac function and exercise tolerance in the patients with DCM, at dosages which do not affect hemodynamics at rest.
A Nakano; M Tamura; M Hatori; A Hasegawa; T Suzuki; K Murata
Related Documents :
7808245 - Endurance athletes' stroke volume does not plateau: major advantage is diastolic function.
7528295 - Effect of alpha 1-adrenergic receptor antagonists on susceptibility to malignant arrhyt...
19155455 - Left ventricular function and exercise capacity.
21459255 - Improving diet and exercise in pregnancy with video doctor counseling: a randomized trial.
16460425 - Self-reported physical activity validated by pedometer: a pilot study.
15793075 - Effect of fluid ingestion on neuromuscular function during prolonged cycling exercise.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  39     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-03-27     Completed Date:  1990-03-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1590-2     Citation Subset:  IM    
Second Department of Internal Medicine, School of Medicine, Gunma University, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenergic alpha-Antagonists / adverse effects,  therapeutic use*
Cardiomyopathy, Dilated / drug therapy*,  physiopathology
Exercise Test*
Hemodynamics / drug effects
Middle Aged
Quinazolines / adverse effects,  therapeutic use*
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Quinazolines; 80755-51-7/bunazosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Influence of various adrenergic compounds on plasma potassium levels in conscious dogs and anaesthet...
Next Document:  A double-blind comparative trial of astemizole and terfenadine for the treatment of hay fever.