| Exercise testing of the chronic effects of bunazosin hydrochloride on dilated cardiomyopathy. | |
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MedLine Citation:
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PMID: 2576205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bunazosin hydrochloride (Detantol) was administrated in 3-mg oral doses to 10 patients (6 males and 4 females, average 49.9 years) with dilated cardiomyopathy (DCM) of class II in the NYHA functional classification. The patients were observed for changes in their hemodynamics at rest, chest X-ray, echocardiography, humoral factors and symptom-limited exercise tolerance with treadmill testing before treatment and 4 and 8 weeks after administration. All but the left ventricular end-diastolic diameter after 8 weeks were unchanged. Of the humoral factors, only aldosterone decreased significantly during the treatment. On the other hand, the duration of symptom-limited exercise was prolonged significantly, and for a given exercise load, a reduction of heart rate and systolic blood pressure as well as a drop in the pressure-rate product occurred at 8 weeks after administration. Therefore, bunazosin appears to improve cardiac function and exercise tolerance in the patients with DCM, at dosages which do not affect hemodynamics at rest. |
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Authors:
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A Nakano; M Tamura; M Hatori; A Hasegawa; T Suzuki; K Murata |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 39 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1990-03-27 Completed Date: 1990-03-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 1590-2 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, School of Medicine, Gunma University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenergic alpha-Antagonists / adverse effects, therapeutic use* Adult Aged Cardiomyopathy, Dilated / drug therapy*, physiopathology Echocardiography Electrocardiography Exercise Test* Female Hemodynamics / drug effects Humans Male Middle Aged Quinazolines / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Quinazolines; 80755-51-7/bunazosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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